COVID-19 is a global pandemic impacting the daily living of millions. As variants of the virus evolve, a complete comprehension of the disease and drug targets becomes a decisive …
H Zhao, Z Cai, J Rao, D Wu, L Ji, R Ye, D Wang… - Molecular Cell, 2024 - cell.com
SARS-CoV-2 RNA interacts with host factors to suppress interferon responses and simultaneously induces cytokine release to drive the development of severe coronavirus …
H Zhang, Z Ouyang, W Zhang - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Bioinformatics has played an important role in analyzing chemical information acquired using mass spectrometry (MS) for large numbers of biological samples. Here we review the …
Multi-omic studies of the human gut microbiome are crucial for understanding its role in disease across multiple functional layers. Nevertheless, integrating and analyzing such …
A Tveita, SL Murphy, JC Holter, AB Kildal… - The Journal of …, 2022 - academic.oup.com
Background Immune dysregulation is a major factor in the development of severe coronavirus disease 2019 (COVID-19). The homeostatic chemokines CCL19 and CCL21 …
MM Khodadoust - Scientific Reports, 2021 - nature.com
A causal relationship between plasma ceramide concentration and respiratory distress symptoms in COVID-19 patients is inferred. In this study, plasma samples of 52 individuals …
M Essex, B Millet Pascual-Leone, U Löber… - npj Biofilms and …, 2024 - nature.com
The clinical course of COVID-19 is variable and often unpredictable. To test the hypothesis that disease progression and inflammatory responses associate with alterations in the …
The drug discovery and development (DDD) process in pursuit of novel drug candidates is a challenging procedure requiring lots of time and resources. Therefore, computer-aided drug …
Cytosolic citrate is imported from the mitochondria by SLC25A1, and from the extracellular milieu by SLC13A5. In the cytosol, citrate is used by ACLY to generate acetyl-CoA, which …