Monkeypox virus (MPXV), which causes disease in humans, has for many years been
restricted to the African continent, with only a handful of sporadic cases in other parts of the …

CD4+ T helper (Th) cells play central roles in immunity in health and disease. While much is
known about the effector function of Th cells in combating pathogens and promoting …

Abstract CD4+ T helper (Th) cells exist in a variety of epigenetic states that determine their
function, phenotype, and capacity for persistence. These polarization states include Th1 …

Th17 cells have been described as short lived, but this view is at odds with their capacity to
trigger protracted damage to normal and transformed tissues. We report that Th17 cells …

COVID-19 (coronavirus disease 2019) caused by SARS-CoV-2 (severe acute respiratory
syndrome coronavirus 2) infection is a disease affecting several organ systems. A model that …

Nanoparticles are primarily taken up by immune cells after systemic administration. Thus,
they are considered an ideal drug delivery vehicle for immunomodulation. Because the …

Studies have shown that the presence of tumor infiltrating lymphocytes (TILs) in Triple
Negative Breast Cancer (TNBC) is associated with better prognosis. However, the molecular …

Effector cells derived from central memory CD8+ T cells were reported to engraft and survive
better than those derived from effector memory populations, suggesting that they are …

CD4+ T cells differentiate into multiple effector types, but it is unclear how they form memory
T cells during infection in vivo. Profiling virus-specific CD4+ T cells revealed that effector …

Regulatory T cells (Tregs) are present in lymphoid and nonlymphoid tissues where they
restrict immune activation, prevent autoimmunity, and regulate inflammation. Tregs in …