[HTML][HTML] The landscape of aging
Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
[HTML][HTML] The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced …
CA Juan, JM Pérez de la Lastra, FJ Plou… - International journal of …, 2021 - mdpi.com
Living species are continuously subjected to all extrinsic forms of reactive oxidants and
others that are produced endogenously. There is extensive literature on the generation and …
others that are produced endogenously. There is extensive literature on the generation and …
[HTML][HTML] International exercise recommendations in older adults (ICFSR): expert consensus guidelines
The human ageing process is universal, ubiquitous and inevitable. Every physiological
function is being continuously diminished. There is a range between two distinct phenotypes …
function is being continuously diminished. There is a range between two distinct phenotypes …
Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?
During aging the immune system (IS) undergoes remarkable changes that collectively are
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …
[HTML][HTML] Immunology of aging: the birth of inflammaging
The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an
evolutionary or rather a revolutionary conceptualization of the immune changes in response …
evolutionary or rather a revolutionary conceptualization of the immune changes in response …
[HTML][HTML] Sex differences in biological aging with a focus on human studies
S Hägg, J Jylhävä - Elife, 2021 - elifesciences.org
Aging is a complex biological process characterized by hallmark features accumulating over
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …
[HTML][HTML] Telomere length as a marker of biological age: state-of-the-art, open issues, and future perspectives
A Vaiserman, D Krasnienkov - Frontiers in Genetics, 2021 - frontiersin.org
Telomere shortening is a well-known hallmark of both cellular senescence and organismal
aging. An accelerated rate of telomere attrition is also a common feature of age-related …
aging. An accelerated rate of telomere attrition is also a common feature of age-related …
[HTML][HTML] Sarcopenia–Molecular mechanisms and open questions
P Wiedmer, T Jung, JP Castro, LCD Pomatto… - Ageing research …, 2021 - Elsevier
Sarcopenia represents a muscle-wasting syndrome characterized by progressive and
generalized degenerative loss of skeletal muscle mass, quality, and strength occurring …
generalized degenerative loss of skeletal muscle mass, quality, and strength occurring …
Undulating changes in human plasma proteome profiles across the lifespan
Aging is a predominant risk factor for several chronic diseases that limit healthspan.
Mechanisms of aging are thus increasingly recognized as potential therapeutic targets …
Mechanisms of aging are thus increasingly recognized as potential therapeutic targets …
[HTML][HTML] Airway remodeling in asthma
KP Hough, ML Curtiss, TJ Blain, RM Liu, J Trevor… - Frontiers in …, 2020 - frontiersin.org
Asthma is an inflammatory disease of the airways that may result from exposure to allergens
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …