Low back pain (LBP) is a leading cause of labour loss and disability worldwide, and it also
imposes a severe economic burden on patients and society. Among symptomatic LBP …

Sirtuins play an important role in signalling pathways associated with various metabolic
regulations. They possess mono-ADP-ribosyltransferase or deacylase activity like …

SIRT1, a member of the sirtuin family of longevity regulators, possesses potent activities
preventing vascular aging. The expression and function of SIRT1 in endothelial cells are …

Sirtuins (SIRTs), enzymes from the family of NAD+-dependent histone deacetylases, play an
important role in the functioning of the body at the cellular level and participate in many …

Emerging evidence indicates that defects in sirtuin signaling contribute to impaired glucose
and lipid metabolism, resulting in insulin resistance (IR) and endothelial dysfunction. Here …

ADP-ribosylation is an ancient posttranslational modification present in all kingdoms of life.
The system likely originated in bacteria where it functions in inter-and intra-species conflict …

Research in biomedical sciences has changed dramatically over the past fifty years. There is
no doubt that the discovery of apoptosis and autophagy as two highly synchronized and …

Abstract Sirtuin 2 (SIRT2) is involved in a wide range of processes, from transcription to
metabolism to genome stability. Dysregulation of SIRT2 has been associated with the …

Sirtuins (SIRTs) are nicotinamide adenine dinucleotide-dependent histone deacetylases
that incorporate complex functions in the mechanisms of cell physiology. Mammals have …

Recent pharmacological research on milk whey, a byproduct of the dairy industry, has
identified several therapeutic properties that could be exploited in modern medicine. In the …