Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Tumorigenesis is accompanied by the reprogramming of cellular metabolism. The shift from
oxidative phosphorylation to predominantly glycolytic pathways to support rapid growth is …

The mechanistic target of rapamycin complex 1 (mTORC1) regulates metabolism and cell
growth in response to nutrient, growth, and oncogenic signals. We found that mTORC1 …

DNA methylation is an epigenetic mechanism that is essential for regulating gene
transcription. However, aberrant DNA methylation, which is a nearly universal finding in …

Autophagy is a mechanism that enables cells to maintain cellular homeostasis by removing
damaged materials and mobilizing energy reserves in conditions of starvation. Although …

Introduction The diagnosis of COVID-19 is normally based on the qualitative detection of
viral nucleic acid sequences. Properties of the host response are not measured but are key …

The polyamines putrescine, spermidine and spermine are widely distributed polycationic
compounds essential for cellular functions. Intracellular polyamine pools are tightly …

The intestinal epithelium has a high turnover rate and constantly renews itself through
proliferation of intestinal crypt cells, which depends on insufficiently characterized signals …

Polyamines, spermidine and spermine, are synthesized in every living cell and are therefore
contained in foods, especially in those that are thought to contribute to health and longevity …

The gut microbiota exists throughout the full life cycle of the human body, and it has been
proven to have extensive impacts on health and disease. Accumulating evidence …