MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

MicroRNAs (miRNAs) are short, regulatory RNAs that act as post-transcriptional repressors
of gene expression in diverse biological contexts. The emergence of small RNA-mediated …

Transcriptome engineering applications in living cells with RNA-targeting CRISPR effectors
depend on accurate prediction of on-target activity and off-target avoidance. Here we design …

Type VI CRISPR enzymes are RNA-targeting proteins with nuclease activity that enable
specific and robust target gene knockdown without altering the genome. To define rules for …

Background Degradation rate is a fundamental aspect of mRNA metabolism, and the factors
governing it remain poorly characterized. Understanding the genetic and biochemical …

MicroRNAs (miRNAs) typically direct degradation of their mRNA targets. However, some
targets have unusual miRNA-binding sites that direct degradation of cognate miRNAs …

Most genes in higher eukaryotes express isoforms with distinct 3'untranslated regions
(3'UTRs), generated by alternative polyadenylation (APA). Since 3'UTRs are predominant …

Abstract 3′ untranslated regions (3′ UTRs) post-transcriptionally regulate mRNA stability,
localization, and translation rate. While 3′-UTR isoforms have been globally quantified in …

The generation of distinct messenger RNA isoforms through alternative RNA processing
modulates the expression and function of genes, often in a cell-type-specific manner. Here …

Background As a new kind of non-coding RNAs (ncRNAs), tRNA derivatives play an
important role in gastric carcinoma (GC). Nevertheless, the underlying mechanism tRNA …