Nutrition is one of the most important factors affecting pubertal development. Puberty entails
a progressive nonlinear process starting from prepubescent to full sexual maturity through …

Congenital cryptorchidism (undescended testis) is one of the most common congenital
urogenital malformations in boys. Prevalence of cryptorchidism at birth among boys born …

Background Gynecomastia (GM) is a benign proliferation of the glandular tissue of the
breast in men. It is a frequent condition with a reported prevalence of 32–65%, depending …

Abstract An Endo-European Reference Network guideline initiative was launched including
16 clinicians experienced in endocrinology, pediatric and adult and 2 patient …

What is already known about this subject There is emerging evidence suggesting that
childhood obesity may influence the timing/tempo of puberty and growth patterns. An earlier …

Testicular growth during puberty is rapid, and mostly due to germ cell expansion and growth
in seminiferous tubule diameter triggered by androgens. Pre-treatment with FSH before the …

The timing of puberty has important public health, clinical, and social implications. The
plasticity of sexual development onset could be a mechanism that adapts to prevailing …

Despite substantial heritability in pubertal development, much variation remains to be
explained, leaving room for the influence of environmental factors to adjust its phenotypic …

Young adults are gaining weight faster than any age group. This weight gain and the
appearance of obesity-related comorbidities often commence in adolescence. Psychosocial …

Little is known about genes regulating male puberty. Further, while many identified pubertal
timing variants associate with age at menarche, a late manifestation of puberty, and body …