Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Malaria is caused by Plasmodium species transmitted by Anopheles mosquitoes. Following
a mosquito bite, Plasmodium sporozoites migrate from skin to liver, where extensive …

CD8+ tissue-resident memory T (T RM) cells play crucial roles in defense against infections
and cancer and have been implicated in autoimmune diseases such as psoriasis. In mice …

Genetically engineered live Plasmodium falciparum sporozoites constitute a potential
platform for creating consistently attenuated, genetically defined, whole-parasite vaccines …

Tissue-resident lymphocytes usually reside in barrier sites and are involved in innate and
adaptive immunity. In recent years, many studies have shown that multiple types of …

Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …

Liver-resident memory CD8+ T (T RM) cells remain in and constantly patrol the liver to elicit
rapid immunity upon antigen encounter and can mediate efficient protection against liver …

Vaccination with infectious Plasmodium falciparum (Pf) sporozoites (SPZ) administered with
antimalarial drugs (PfSPZ-CVac), confers superior sterilizing protection against infection …

Circulating memory CD8 T cell trafficking and protective capacity during liver-stage malaria
infection remains undefined. We find that effector memory CD8 T cells (Tem) infiltrate the …