Prenatal exposures to endocrine disrupting chemicals: The role of multi-omics in understanding toxicity

MH Rabotnick, J Ehlinger, A Haidari… - Molecular and Cellular …, 2023 - Elsevier
Endocrine disrupting chemicals (EDCs) are a diverse group of toxicants detected in
populations globally. Prenatal EDC exposures impact birth and childhood outcomes. EDCs …

[HTML][HTML] Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons

AG Paquette, S Lapehn, S Freije, J MacDonald… - Environment …, 2023 - Elsevier
Abstract Background Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants
originating from petrogenic and pyrogenic sources. PAH compounds can cross the placenta …

[HTML][HTML] Prenatal exposure to polycyclic aromatic hydrocarbons and cognition in early childhood

B Sun, ER Wallace, Y Ni, CT Loftus, A Szpiro… - Environment …, 2023 - Elsevier
Background Epidemiological evidence for gestational polycyclic aromatic hydrocarbon
(PAH) exposure and adverse child cognitive outcomes is mixed; little is known about critical …

[HTML][HTML] Prenatal exposures to phthalates and life events stressors in relation to child behavior at age 4–6: A combined cohort analysis

ES Barrett, DB Day, A Szpiro, J Peng, CT Loftus… - Environment …, 2024 - Elsevier
Prenatal exposures to chemical and psychosocial stressors can impact the developing
brain, but few studies have examined their joint effects. We examined associations between …

Prenatal exposure to polycyclic aromatic hydrocarbons is not associated with behavior problems in preschool and early school-aged children: A prospective multi …

ER Wallace, E Buth, AA Szpiro, Y Ni, CT Loftus… - Environmental …, 2023 - Elsevier
Background Epidemiological study findings are inconsistent regarding associations
between prenatal polycyclic aromatic hydrocarbon (PAH) exposures and childhood …

Placental transcriptomic signatures of prenatal and preconceptional maternal stress

BH Baker, S Freije, JW MacDonald, TK Bammler… - Molecular …, 2024 - nature.com
Prenatal exposure to maternal psychological stress is associated with increased risk for
adverse birth and child health outcomes. Accumulating evidence suggests that …

A multi-cohort examination of the independent contributions of maternal childhood adversity and pregnancy stressors to the prediction of children's anxiety and …

A Noroña-Zhou, M Coccia, A Sullivan… - Research on Child and …, 2023 - Springer
Women's social experiences can have long-term implications for their offspring's health, but
little is known about the potential independent contributions of multiple periods of stress …

Prenatal polycyclic aromatic hydrocarbon exposure and asthma at age 8–9 years in a multi-site longitudinal study

AR Sherris, CT Loftus, AA Szpiro, LC Dearborn… - Environmental …, 2024 - Springer
Background and aim Studies suggest prenatal exposure to polycyclic aromatic
hydrocarbons (PAHs) may influence wheezing or asthma in preschool-aged children …

A genome scale transcriptional regulatory model of the human placenta

A Paquette, K Ahuna, YM Hwang, J Pearl, H Liao… - Science …, 2024 - science.org
Gene regulation is essential to placental function and fetal development. We built a genome-
scale transcriptional regulatory network (TRN) of the human placenta using digital genomic …

Characterization of xenobiotic and steroid disposition potential of human placental tissue and cell lines (BeWo, JEG-3, JAR, and HTR-8/SVneo) by quantitative …

L Kruger, S Lapehn, A Paquette, DK Singh… - Drug Metabolism and …, 2023 - ASPET
The placenta is a fetal organ that performs critical functions to maintain pregnancy and
support fetal development, including metabolism and transport of xenobiotics and steroids …