Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

The past decade has witnessed a great leap forward in bacteria-based living agents,
including imageable probes, diagnostic reagents, and therapeutics, by virtue of their unique …

Synergistic phototherapy stands for superior treatment prospects than a single
phototherapeutic modality. However, the combined photosensitizers often suffer from …

Synthetic biology aims to design or assemble existing bioparts or bio-components for useful
bioproperties. During the past decades, progresses have been made to build delicate …

Oral probiotic therapy has become an increasingly attractive method for treating various
diseases, including intestinal barrier dysfunction, inflammatory bowel disease (IBD), and …

The clinical application of orally delivered probiotics as live therapeutics in the treatment of
colitis is hampered by suboptimal bacterial bioactivity and inadequate gut retention. Here …

Despite decades of research, cancer continues to be a major global health concern. The
human mouth appears to be a multiplicity of local environments communicating with other …

The idea of using engineered bacteria as prospective living therapeutic agents for the
treatment of different diseases has been raised. Nevertheless, the development of safe and …

Activating antigen-presenting cells is essential to generate adaptive immunity, while the
efficacy of conventional activation strategies remains unsatisfactory due to suboptimal …

Adequate intake of live probiotics is beneficial to human health and wellbeing because they
can help treat or prevent a variety of health conditions. However, the viability of probiotics is …