Targeting SARS-CoV-2 entry processes: The promising potential and future of host-targeted small-molecule inhibitors

A Wu, K Shi, J Wang, R Zhang, Y Wang - European Journal of Medicinal …, 2023 - Elsevier
The COVID-19 pandemic, caused by SARS-CoV-2, has had a huge impact on global health.
To respond to rapidly mutating viruses and to prepare for the next pandemic, there is an …

Metabolic regulation of type I interferon production

SM O'Carroll, FDR Henkel… - Immunological Reviews, 2024 - Wiley Online Library
Over the past decade, there has been a surge in discoveries of how metabolic pathways
regulate immune cell function in health and disease, establishing the field of …

[HTML][HTML] Lipid Metabolism Modulation during SARS-CoV-2 Infection: A Spotlight on Extracellular Vesicles and Therapeutic Prospects

H D'Avila, CNR Lima, PG Rampinelli… - International Journal of …, 2024 - mdpi.com
Extracellular vesicles (EVs) have a significant impact on the pathophysiological processes
associated with various diseases such as tumors, inflammation, and infection. They exhibit …

[HTML][HTML] Genomic communication via circulating extracellular vesicles and long-term health consequences of COVID-19

S Nair, E Nova-Lamperti, G Labarca… - Journal of Translational …, 2023 - Springer
COVID-19 continues to affect an unprecedented number of people with the emergence of
new variants posing a serious challenge to global health. There is an expansion of …

Host factors of SARS-CoV-2 in infection, pathogenesis, and long-term effects

Y Zhang, S Chen, Y Tian, X Fu - Frontiers in Cellular and Infection …, 2024 - frontiersin.org
SARS-CoV-2 is the causative virus of the devastating COVID-19 pandemic that results in an
unparalleled global health and economic crisis. Despite unprecedented scientific efforts and …

[HTML][HTML] Pre-Infection Innate Immunity Attenuates SARS-CoV-2 Infection and Viral Load in iPSC-Derived Alveolar Epithelial Type 2 Cells

S Kumar, J Granados, M Aceves, J Peralta… - Cells, 2024 - mdpi.com
A large portion of the heterogeneity in coronavirus disease 2019 (COVID-19) susceptibility
and severity of illness (SOI) remains poorly understood. Recent evidence suggests that …

[HTML][HTML] 1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit

J Nahalka - International Journal of Molecular Sciences, 2024 - mdpi.com
The COVID-19 pandemic prompted rapid research on SARS-CoV-2 pathogenicity.
Consequently, new data can be used to advance the molecular understanding of SARS …

[HTML][HTML] Effect of the SARS-CoV-2 pandemic on metabolic control in patients with type 2 diabetes: a 5-year cohort follow-up managed by a dynamic multidisciplinary …

DP Morales-Rodriguez, A González-Cantú… - Diabetology & Metabolic …, 2024 - Springer
Abstract Background The SARS-CoV-2 pandemic brought a radical shift in the healthcare
system and suboptimal care for vulnerable patients, such as those with Type 2 Diabetes …

[HTML][HTML] Association between Lipid Levels, Anti-SARS-CoV-2 Spike Antibodies and COVID-19 Mortality: A Prospective Cohort Study

S Mink, CH Saely, M Frick, A Leiherer, H Drexel… - Journal of Clinical …, 2023 - mdpi.com
Background: Recent studies suggest that both lipid levels and anti-severe-acute-respiratory-
syndrome-coronavirus-2 (SARS-CoV-2) antibody levels are associated with outcome in …

[HTML][HTML] Decoding HiPSC-CM's Response to SARS-CoV-2: mapping the molecular landscape of cardiac injury

S Chen, Z Fu, K Chen, X Zheng, Z Fu - BMC genomics, 2024 - Springer
Background Acute cardiac injury caused by coronavirus disease 2019 (COVID-19)
increases mortality. Acute cardiac injury caused by COVID-19 requires understanding how …