Microglia, the major population of brain‐resident macrophages, are now recognized as a
heterogeneous population comprising several cell subtypes with different (so far mostly …

Genome-wide association studies (GWASs) provide a key foundation for elucidating the
genetic underpinnings of common polygenic diseases. However, these studies have …

Previous studies on genetic diseases predominantly focused on protein-coding variations,
overlooking the vast noncoding regions in the human genome. The development of high …

Cistrome‐wide association studies (CWAS) are pivotal for identifying genetic determinants
of diseases by correlating genetically regulated cistrome states with phenotypes. Traditional …

Genetic predisposition to cardiac arrhythmias has been a field of intense investigation.
Research initially focused on rare hereditary arrhythmias, but over the last two decades, the …

Endothelial cell (EC) dysfunction is a common mechanism that can drive, and contribute
substantially, to a broad range of cardiovascular diseases (CVDs). Endothelial cells are a …

The primary cellular substrates of atrial fibrillation (AF) and the mechanisms underlying AF
onset remain poorly characterized and therefore, its risk assessment lacks precision. While …

Nucleotide variants in cell type–specific gene regulatory elements in the human brain are
risk factors for human disease. We measured chromatin accessibility in 1932 aliquots of …

Current treatments are ineffective to cure or prevent occurrences of autoimmune psoriasis
and psoriatic cardiovascular disease/CVD. Psoriasis is associated with deregulated …

Background: Kidney diseases pose a significant global health burden; there is an urgent
need to deepen our understanding of their underlying mechanisms. Summary: This review …