Revolutionizing SARS-CoV-2 omicron variant detection: Towards faster and more reliable methods

D Li, C Sun, P Zhuang, X Mei - Talanta, 2024 - Elsevier
The emergence of the highly contagious Omicron variant of SARS-CoV-2 has inflicted
significant damage during the ongoing COVID-19 pandemic. This new variant's significant …

Small Antibodies with Big Applications: Nanobody-Based Cancer Diagnostics and Therapeutics

Q Zhang, N Zhang, H Xiao, C Wang, L He - Cancers, 2023 - mdpi.com
Simple Summary Cancer is a leading cause of death worldwide, accounting for nearly one
in six deaths. The most common cancers are lung, breast, colon, rectum and prostate …

Plant virus‐derived nanoparticles decorated with genetically encoded SARS‐CoV‐2 nanobodies display enhanced neutralizing activity

F Merwaiss, E Lozano‐Sanchez… - Plant Biotechnology …, 2024 - Wiley Online Library
Viral nanoparticles (VNPs) are a new class of virus‐based formulations that can be used as
building blocks to implement a variety of functions of potential interest in biotechnology and …

Anti-Idiotypic Nanobody Alkaline Phosphatase Fusion Protein-Triggered On–Off–On Fluorescence Immunosensor for Aflatoxin in Cereals

G Yu, J Wang, Y Zhang, H Wu, Y Wang… - Journal of Agricultural …, 2023 - ACS Publications
Nanobodies (Nbs) are widely used in immunoassays with the advantages of small size and
high stability. Here, the nanobody employed as the surrogate of aflatoxin antigen and the …

Screening, expression and identification of nanobody against monkeypox virus A35R

N Meng, X Cheng, M Sun, Y Zhang, X Sun… - International Journal …, 2023 - Taylor & Francis
Introduction The monkeypox (Mpox) virus epidemic presents a significant risk to global
public health security. A35R, a crucial constituent of EEV, plays a pivotal role in virus …

Structure basis of two nanobodies neutralizing SARS-CoV-2 Omicron variant by targeting ultra-conservative epitopes

Z Sun, L Wang, L Li, Y Sun, D Zhang, S Zhou… - Journal of Structural …, 2023 - Elsevier
Abstract The evolving SARS-CoV-2 Omicron strain has repeatedly caused widespread
disease epidemics, and effective antibody drugs continue to be in short supply. Here, we …

Protein Nanoparticles as Vaccine Platforms for Human and Zoonotic Viruses

KK Pandey, BR Sahoo, AK Pattnaik - Viruses, 2024 - mdpi.com
Vaccines are one of the most effective medical interventions, playing a pivotal role in treating
infectious diseases. Although traditional vaccines comprise killed, inactivated, or live …

Protection against the H1N1 influenza virus using self-assembled nanoparticles formed by lumazine synthase and bearing the M2e peptide

H Zhu, X Li, X Li, H Chen, P Qian - Virology, 2024 - Elsevier
There is an urgent need for influenza vaccines that offer broad cross-protection. The highly
conserved ectodomain of the influenza matrix protein 2 (M2e) is a promising candidate; …

Rapid and highly potent humoral responses to mpox nanovaccine candidates adjuvanted by thermostable scaffolds

H Yan, Y Peng, J Zhang, R Peng, XN Feng, JY Su… - Vaccine, 2024 - Elsevier
Monkeypox (mpox) is a zoonotic disease caused by monkeypox virus (MPXV) of the
orthopoxvirus genus. The emergence and global spread of mpox in 2022 was declared as a …

Asymmetric assembly and self-adjuvanted antigen delivery platform for improved antigen uptake and antitumor effect

J Yang, J Zhang, P Yan, Z Zhang, W Gao… - Bioconjugate …, 2023 - ACS Publications
The development of effective tumor vaccines is an important direction in the field of cancer
prevention/immunotherapy. Efficient antigen delivery is essential for inducing effective …