Drug combinations as a first line of defense against coronaviruses and other emerging viruses
The world was unprepared for coronavirus disease 2019 (COVID-19) and remains ill-
equipped for future pandemics. While unprecedented strides have been made developing …
equipped for future pandemics. While unprecedented strides have been made developing …
How antibodies recognize pathogenic viruses: Structural correlates of antibody neutralization of HIV-1, SARS-CoV-2, and Zika
The H1N1 pandemic of 2009-2010, MERS epidemic of 2012, Ebola epidemics of 2013-2016
and 2018-2020, Zika epidemic of 2015-2016, and COVID-19 pandemic of 2019-2021, are …
and 2018-2020, Zika epidemic of 2015-2016, and COVID-19 pandemic of 2019-2021, are …
Leveraging Artificial Intelligence to Expedite Antibody Design and Enhance Antibody–Antigen Interactions
This perspective sheds light on the transformative impact of recent computational
advancements in the field of protein therapeutics, with a particular focus on the design and …
advancements in the field of protein therapeutics, with a particular focus on the design and …
Recent advances in infectious disease research using cryo-electron tomography
D Asarnow, VA Becker, D Bobe… - Frontiers in Molecular …, 2024 - frontiersin.org
With the increasing spread of infectious diseases worldwide, there is an urgent need for
novel strategies to combat them. Cryogenic sample electron microscopy (cryo-EM) …
novel strategies to combat them. Cryogenic sample electron microscopy (cryo-EM) …
Analytical Ultracentrifugation Detects Quaternary Rearrangements and Antibody-Induced Conformational Selection of the SARS-CoV-2 Spike Trimer
G Guerrini, D Mehn, F Fumagalli, S Gioria… - International Journal of …, 2023 - mdpi.com
Analytical ultracentrifugation (AUC) analysis shows that the SARS-CoV-2 trimeric Spike (S)
protein adopts different quaternary conformations in solution. The relative abundance of the …
protein adopts different quaternary conformations in solution. The relative abundance of the …
Inhibition of respiratory syncytial virus by Daclatasvir and its derivatives: synthesis of computational derivatives as a new drug development
D Mitra, S Afreen, PK Das Mohapatra… - Journal of Biomolecular …, 2023 - Taylor & Francis
The most common cause of respiratory tract illness in newborns and young children is the
respiratory syncytial virus (RSV). There is no approved vaccination or specific antiviral …
respiratory syncytial virus (RSV). There is no approved vaccination or specific antiviral …
A general computational design strategy for stabilizing viral class I fusion proteins
Many pathogenic viruses rely on class I fusion proteins to fuse their viral membrane with the
host cell membrane. To drive the fusion process, class I fusion proteins undergo an …
host cell membrane. To drive the fusion process, class I fusion proteins undergo an …
Computational Modeling in the Development of Antiviral Agents
As a result of the damage that viruses have done over time, humans have developed a
variety of defenses against viral illnesses, such as vaccines and antiviral drugs for treatment …
variety of defenses against viral illnesses, such as vaccines and antiviral drugs for treatment …
Antigen binding molecules targeting SARS-CoV-2
F Borriello, AH Ramos - US Patent 11,993,644, 2024 - Google Patents
BNMFQWUHWYJTRI-BQFCYCMXSA-N 7-chloro-N-[(2S)-1-[[(1S)-1-cyano-2-[(3S)-2-
oxopiperidin-3-yl] ethyl] amino]-3-cyclopropyl-1-oxopropan-2-yl]-1H-indole-2-carboxamide …
oxopiperidin-3-yl] ethyl] amino]-3-cyclopropyl-1-oxopropan-2-yl]-1H-indole-2-carboxamide …
Antigen binding molecules targeting SARS-CoV-2
G Grigoryan, J Ingraham - US Patent 11,987,616, 2024 - Google Patents
The invention provides, in various embodiments, polypeptides (eg, camelid antibodies and
antigen binding fragments thereof) that specifically bind to Spike glycoprotein of severe …
antigen binding fragments thereof) that specifically bind to Spike glycoprotein of severe …