[HTML][HTML] Applying the digital data and the bioinformatics tools in SARS-CoV-2 research

M Tan, J Xia, H Luo, G Meng, Z Zhu - Computational and Structural …, 2023 - Elsevier
Bioinformatics has been playing a crucial role in the scientific progress to fight against the
pandemic of the coronavirus disease 2019 (COVID-19) caused by the severe acute …

Advances in analyzing virus-induced alterations of host cell splicing

U Ashraf, C Benoit-Pilven, V Lacroix, V Navratil… - Trends in …, 2019 - cell.com
Alteration of host cell splicing is a common feature of many viral infections which is
underappreciated because of the complexity and technical difficulty of studying alternative …

[HTML][HTML] Bioinformatics and systems biology approach to identify the pathogenetic link of Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Y Lv, T Zhang, J Cai, C Huang, S Zhan… - Frontiers in …, 2022 - frontiersin.org
Background The COVID-19 pandemic, caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a global crisis. Although many people recover from COVID …

Systems biology, systems medicine, systems pharmacology: the what and the why

A Stéphanou, E Fanchon, PF Innominato, A Ballesta - Acta biotheoretica, 2018 - Springer
Abstract Systems biology is today such a widespread discipline that it becomes difficult to
propose a clear definition of what it really is. For some, it remains restricted to the genomic …

Evolution of Bioinformatics and its impact on modern bio-science in the twenty-first century: Special attention to pharmacology, plant science and drug discovery

D Mitra, D Mitra, MS Bensaad, S Sinha, K Pant… - Computational …, 2022 - Elsevier
Bioinformatics is inherently an innovative field that is situated at the limit of life and computer
sciences that allowed new technological advances in genome sequencing, data processing …

[HTML][HTML] Applying systems biology to biomedical research and health care: a précising definition of systems medicine

S Schleidgen, S Fernau, H Fleischer… - BMC health services …, 2017 - Springer
Background Systems medicine has become a key word in biomedical research. Although it
is often referred to as P4-(predictive, preventive, personalized and participatory)-medicine, it …

Network pharmacology analysis and experiments validation of the inhibitory effect of JianPi Fu recipe on colorectal cancer LoVo cells metastasis and growth

X Lu, X Wu, L Jing, L Tao, Y Zhang… - Evidence‐Based …, 2020 - Wiley Online Library
Objective. To analyze the active compounds, potential targets, and diseases of JianPi Fu
Recipe (JPFR) based on network pharmacology and bioinformatics and verify the potential …

[HTML][HTML] Systems medicine 2030: A Delphi study on implementation in the German healthcare system

C Lemmen, C Woopen, S Stock - Health Policy, 2021 - Elsevier
Introduction Systems medicine is based on approaches taken from systems biology, omics
research, bio-informatics and network theory. It promises to facilitate a better understanding …

Application of pharmacometrics and quantitative systems pharmacology to cancer therapy: The example of luminal a breast cancer

B Fleisher, AN Brown, S Ait-Oudhia - Pharmacological Research, 2017 - Elsevier
Breast cancer (BC) is the most common cancer in women, and the second most frequent
cause of cancer-related deaths in women worldwide. It is a heterogeneous disease …

[HTML][HTML] Data challenges of biomedical researchers in the age of omics

R Garcia-Milian, D Hersey, M Vukmirovic, F Duprilot - PeerJ, 2018 - peerj.com
Background High-throughput technologies are rapidly generating large amounts of diverse
omics data. Although this offers a great opportunity, it also poses great challenges as data …