In these days when molecular biology reins, new discoveriesare made at such a fast pace
that one's perspectiveoften covers only a small time frame. In this article my intention is to …

Despite being inert and nontoxic, implanted biomaterials often trigger adverse foreign body
reactions such as inflammation, fibrosis, infection, and thrombosis. With regard to the …

Fibrinogen is a thrombin-coagulable glycoprotein occurring in the blood of vertebrates. The
primary structure of the α, β, and γ polypeptide chains of human fibrinogen is known from …

Fibrin and hyaluronic acid (HA) are macromolecules whose concentrations are elevated at
the same time in the extracellular space of damaged tissues. We have investigated whether …

Achieving good clinical outcomes with implanted biomaterials depends upon achieving
optimal function, both mechanical and biological, which in turn depends upon integrating …

Recently, we described a method of testing platelet deposition on extracellular matrix under
flow conditions. The method was used for assessment of platelet function in various platelet …

We investigated the whole cell distribution of the platelet membrane receptor for fibrinogen
in surface-activated human platelets. Fibrinogen-labeled colloidal gold was used in …

The effect of fibrinogen and fibrinogen-derived products on the velocity of rouleau formation
of human erythrocytes was quantitatively examined with a rheoscope combined with a video …

In agreement with previous studies, we observed that incubation of washed human platelets
with EDTA at 37 degrees C for short periods caused an irreversible loss of their aggregation …

We have previously reported that maximal platelet activation with adenosine diphosphate
(100 microM ADP) causes rapid expression of all GPIIb-IIIa receptors for fibrinogen (FgR)(< …