The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Lineage studies conducted in the retina more than 25 years ago demonstrated the
multipotency of retinal progenitor cells (RPCs). The number and types of cells produced by …

Local mRNA translation mediates the adaptive responses of axons to extrinsic signals, but
direct evidence that it occurs in mammalian CNS axons in vivo is scant. We developed an …

Injured neurons in the adult mammalian central nervous system often die and seldom
regenerate axons. To uncover transcriptional pathways that could ameliorate these …

Vascular development in the mammalian retina is a paradigm for CNS vascular
development in general, and its study is revealing fundamental mechanisms that explain the …

Detailed analysis of neuronal network architecture requires the development of new
methods. Here we present strategies to visualize synaptic circuits by genetically labelling …

Localized mRNA translation regulates synapse function and axon maintenance, but how
compartment-specific mRNA repertoires are regulated is largely unknown. We developed an …

The large number of candidate genes made available by comprehensive genome analysis
requires that relatively rapid techniques for the study of function be developed. Here, we …

Gene regulatory networks (GRNs), consisting of transcription factors and their target sites,
control neurogenesis and cell-fate specification in the developing central nervous system. In …

Vascular and nervous systems, two major networks in mammalian bodies, show a high
degree of anatomical parallelism and functional crosstalk. During development, neurons …