The antigen-specific primary activation of CD4+ T cells was studied in vivo by adoptive
transfer of ovalbumin-specific transgenic T cells (KJ1-26+ CD4+) following intranasal …

Urinary tract infections (UTIs) caused by Escherichia coli and Proteus mirabilis are an
important cause of morbidity and with the high rate of relapse and spread of multi-drug …

Streptococcus gordonii is a bacterial vaccine vector which has previously been shown to
activate dendritic cells in vitro and to induce local and systemic immune responses in vivo. In …

Bacterial cell division ends with the separation of the daughter cells, a process that requires
peptidoglycan hydrolases (PGHs). Bacteria lacking cell separating PGHs are impaired in …

Vaccinations against various antigens of the central nervous system (CNS) are gaining
increasing interest as a therapeutic approach in a variety of neurological diseases such as …

Novel surface proteins can be introduced onto bacterial cell surfaces by recombinant
means. Here, we describe various applications of two such display systems for the food …

The ubiquitous skin colonist Staphylococcus epidermidis elicits a CD8+ T cell response pre-
emptively, in the absence of an infection1. However, the scope and purpose of this anti …

ABSTRACT A nontoxic mutant diphtheria toxin fragment A (DTA) was genetically fused in
single, double, or triple copy to the major surface protein antigen P1 (SpaP) and surface …

Cell-surface display is the expression of peptides and proteins on the surface of living cells
by fusing them tofunctional components of cells which are exposed to the environment of …

Ovarian cancer is known for its poor neoantigen expression and strong immunosuppression.
Here, we utilized an attenuated non-pathogenic bacterium Listeria monocytogenes …