Streptococcus gordonii, an oral commensal organism, is a candidate vector for oral-vaccine
development. Previous studies have shown that recombinant S. gordonii expressing …

The development of effective strategies for the delivery of vaccine antigens to the mucosal
tissues has received considerable attention over the past decade (reviewed in Michalek et …

Pertussis toxoid, diphtheria toxoid, and tetanus toxoid are key components of diphtheria–
tetanus–acellular pertussis vaccines. The efficacy of the vaccines is well documented …

Gram-positive bacterium Streptococcus gordonii, a human oral commensal, was engineered
to display a single-chain Fv (scFv) antibody fragment at the cell surface. The previously …

Tetanus is a disease caused by tetanus toxin, a potent inhibitor for the release of inhibitory
neurotransmitter in the central nervous system that causes spastic paralysis. Fragment C (52 …

Several key protein structural attributes were altered in an effort to optimize expression and
immunogenicity of a foreign protein (M protein from Streptococcus pyogenes) exposed on …

Enterhemorrhagic Escherichia coli (EPEC), an important cause of severe infantile diarrheal
disease in many parts of the developing world, produced several recently described …

Following the anthrax attacks of 2001 and the recent SARS outbreak, concerns about
emerging and re-emerging infectious diseases have catalyzed a renewed interest in …

Most interactions between host and pathogens occur at the host mucos al surfaces. Many
pathogens, such as the human immunodeficiency virus (HIV), gain entry via the mucosa …

Schistosomiasis is a worldwide parasitic disease. Currently, chemotherapy is the main
effective method to treat schistosomiasis; however, it does not prevent reinfection. No …