Schistosomiasis is a worldwide parasitic disease. Currently, chemotherapy is the main
effective method to treat schistosomiasis; however, it does not prevent reinfection. No …

The Inucosal surfaces of the gastrointestinal, genitourinary, oral and respiratory systems
represent the principal portals ofentry for Jnost pathogenic rnicroorganislns, as well as the …

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The food-grade Gram-positive bacterium, Lactococcus lactis, is recognized as a potential
candidate to deliver proteins of medical interest by mucosal routes. The ability of carrier …

The present invention provides a composition comprising a chimeric polypeptide comprising
a recall antigen that reac tivates memory T cells in a Subject and a new antigen that …

The ability to prime the immune system against an antigen, and to rapidly recall this
response upon antigen reencounter is a fundamental characteristic of the adaptive immune …

Background In the past ten years there has been a growing interest in engineering Gram-
positive bacteria for biotechnological applications, including vaccine delivery and production …

Pneumonia is a deadly respiratory disease inflicting millions of people in third world
countries. Current vaccination strategies which include polysaccharide-based vaccines are …

We developed a novel surface display system based on the CotB anchoring motif in order to
express foreign protein on the surface of vegetative Bacillus subtilis cells. CotB is a protein …

黏膜是许多病原体入侵机体的第一道屏障. 黏膜免疫能在这些病原体的入口抑制其感染机体,
作用机制主要有: 防止病原体黏附宿主细胞; 干扰病原体的转录和正确组装; 促进抗原呈递 …