Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to
induce strong inflammatory responses that defend the host against microbe infection …

Most rheumatic and musculoskeletal diseases (RMDs) can be placed along a spectrum of
disorders, with autoinflammatory diseases (including monogenic systemic autoinflammatory …

Sepsis is a life-threatening organ dysfunction responsible for nearly 270,000 deaths
annually in the United States alone. Nicotinamide adenine dinucleotide (NAD+), an …

Osteoporosis is a systemic bone metabolism disease that often causes complications, such
as fractures, and increases the risk of death. The nucleotide-binding oligomerization domain …

NOD-like receptor protein 3 (NLRP3), an important intracellular pattern recognition receptor,
is a component of the NLRP3 inflammasome along with apoptosis-associated speck-like …

In the early 2000s, caspase-1, an important molecule that has been shown to be involved in
the regulation of inflammation, cell survival and diseases, was given a new function …

Chronic pain affects the life quality of the suffering patients and posts heavy problems to the
health care system. Conventional medications are usually insufficient for chronic pain …

Gout is an autoinflammatory disease caused by the deposition of urate crystals. As the most
common inflammatory arthritis, gout has a high incidence and can induce various severe …

In the panorama of inflammatory arthritis, gout is the most common and studied disease. It is
known that hyperuricemia and monosodium urate (MSU) crystal-induced inflammation …

MCC950 has been proposed as a specific small molecule inhibitor that can selectively block
NLRP3 inflammasome activation. However, the exact mechanism of its action is still …