Oral metal–organic gel protected whole-cell biosensor for in situ monitoring nitrosamines in the gastrointestinal Tract

HS Wang, XY Wang, HT Ding, XY Hu, J Li, C Cheng… - Nano Letters, 2022 - ACS Publications
Nitrite, a type of food additive, has been proved convertible to genotoxic nitrosamines in the
gastrointestinal tract by intestinal flora. There is no appropriate method for in situ detection of …

Machine learning-based biomarkers identification from toxicogenomics–Bridging to regulatory relevant phenotypic endpoints

SM Rahman, J Lan, D Kaeli, J Dy… - Journal of hazardous …, 2022 - Elsevier
One of the major challenges in realization and implementations of the Tox21 vision is the
urgent need to establish quantitative link between in-vitro assay molecular endpoint and in …

Summation of disinfection by-product CHO cell relative toxicity indices: sampling bias, uncertainty, and a path forward

E McKenna, KA Thompson… - … Science: Processes & …, 2020 - pubs.rsc.org
The cyto-and genotoxic potencies of disinfection by-products (DBPs) have been evaluated
in published literature by measuring the response of exposed Chinese hamster ovary cells …

Advances in toxicity assessment of drinking water disinfection byproducts

Z Xie, J Guan, X Lei, M Fan, J Qiu, X Yang - TrAC Trends in Analytical …, 2024 - Elsevier
Drinking water disinfection is crucial for the elimination of pathogens and the prevention of
waterborne diseases. However, this process also results in the formation of numerous …

Review of ecologically relevant in vitro bioassays to supplement current in vivo tests for whole effluent toxicity testing-Part 2: Non-apical endpoints

KA Finlayson, JP Van de Merwe, FDL Leusch - Science of The Total …, 2022 - Elsevier
Whole effluent toxicity (WET) testing uses whole animal exposures to assess the toxicity of
complex mixtures, like wastewater. These assessments typically include four apical …

Treatment of cooling tower blowdown water by using adsorption-electrocatalytic oxidation: Technical performance, toxicity assessment and economic evaluation

X Li, L Wu, S Lu, H Yang, W Xie, H Zhao… - Separation and …, 2020 - Elsevier
An eco-friendly process was adopted to treat cooling tower blowdown water (CTBD) and the
toxicity of correspondingly produced water/eluate was evaluated using the transcriptional …

Chronic exposure to dichloroacetamide induces biochemical and histopathological changes in the gills of zebrafish

Y Zhang, HJ Sun, JY Zhang… - Environmental …, 2019 - Wiley Online Library
To evaluate the impact of DCAcAm on zebrafish gill, we measure the responses of
antioxidant enzyme (superoxide dismutase, SOD), lipid peroxidation (malondialdehyde …

[HTML][HTML] The alternation of halobenzoquinone disinfection byproduct on toxicogenomics of DNA damage and repair in uroepithelial cells

X Zhang, L Liu, J Wang, L Liang, X Wang… - Environment …, 2024 - Elsevier
Halobenzoquinones (HBQs) were recently discovered as an emerging class of drinking
water disinfection byproducts with carcinogenic concern. However, the molecular …

Multi-endpoint toxicity tests and effect-targeting risk assessment of surface water and pollution sources in a typical rural area in the Yellow River Basin, China

F Li, J Tan, Q Yang, M He, R Yu, C Liu, X Zhou - Chemosensors, 2022 - mdpi.com
Multi-endpoint toxicity tests were used to evaluate the acute toxicity, estrogenic activity,
neurotoxicity, genotoxicity, and ecological risks of surface water and sewage from possible …

Effects of iodoacetic acid drinking water disinfection byproduct on the gut microbiota and its metabolism in rats

Y Sha, H Wu, Y Guo, X Liu, Y Mo, Q Yang, S Wei… - Journal of …, 2022 - Elsevier
Iodoacetic acid (IAA) is an unregulated disinfection byproduct in drinking water and has
been shown to exert cytotoxicity, genotoxicity, tumorigenicity, and reproductive and …