[HTML][HTML] Mitochondrial dysfunction and oxidative stress in Alzheimer's disease

A Misrani, S Tabassum, L Yang - Frontiers in aging neuroscience, 2021 - frontiersin.org
Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …

Homocysteine and mitochondria in cardiovascular and cerebrovascular systems

P Kaplan, Z Tatarkova, MK Sivonova, P Racay… - International journal of …, 2020 - mdpi.com
Elevated concentration of homocysteine (Hcy) in the blood plasma, hyperhomocysteinemia
(HHcy), has been implicated in various disorders, including cardiovascular and …

Antioxidant effects of protocatechuic acid and protocatechuic aldehyde: old wine in a new bottle

S Zhang, Z Gai, T Gui, J Chen… - Evidence‐Based …, 2021 - Wiley Online Library
Phenolic compounds are naturally present as secondary metabolites in plant‐based
sources such as fruits, vegetables, and spices. They have received considerable attention …

Deregulated mitochondrial microRNAs in Alzheimer's disease: focus on synapse and mitochondria

P Gowda, PH Reddy, S Kumar - Ageing research reviews, 2022 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia and is currently one of the
biggest public health concerns in the world. Mitochondrial dysfunction in neurons is one of …

Mitochondria-targeted antioxidants, an innovative class of antioxidant compounds for neurodegenerative diseases: perspectives and limitations

M Fields, A Marcuzzi, A Gonelli, C Celeghini… - International journal of …, 2023 - mdpi.com
Neurodegenerative diseases comprise a wide spectrum of pathologies characterized by
progressive loss of neuronal functions and structures. Despite having different genetic …

Structure, mechanism, and regulation of mitochondrial DNA transcription initiation

U Basu, AM Bostwick, K Das… - Journal of Biological …, 2020 - ASBMB
Mitochondria are specialized compartments that produce requisite ATP to fuel cellular
functions and serve as centers of metabolite processing, cellular signaling, and apoptosis …

Disentangling mitochondria in Alzheimer's disease

A Johri - International journal of molecular sciences, 2021 - mdpi.com
Alzheimer's disease (AD) is a major cause of dementia in older adults and is fast becoming
a major societal and economic burden due to an increase in life expectancy. Age seems to …

Dietary plant polyphenols as the potential drugs in neurodegenerative diseases: current evidence, advances, and opportunities

L Yan, MS Guo, Y Zhang, L Yu, JM Wu… - Oxidative Medicine …, 2022 - Wiley Online Library
Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD),
and Huntington's disease (HD), are characterized by the progressive degeneration of …

Walnut-derived peptide enhances mitophagy via JNK-mediated PINK1 activation to reduce oxidative stress in HT-22 cells

J Yang, L Fang, H Lu, C Liu, J Wang… - Journal of Agricultural …, 2022 - ACS Publications
Mitophagy has a neuroprotective effect on reactive oxygen species (ROS)-induced
neurodegenerative diseases. The walnut-derived polypeptide (TW-7) has antioxidant activity …

Neuroprotective effects of agri-food by-products rich in phenolic compounds

A Rojas-García, Á Fernández-Ochoa, ML Cádiz-Gurrea… - Nutrients, 2023 - mdpi.com
Neurodegenerative diseases are known for their wide range of harmful conditions related to
progressive cell damage, nervous system connections and neuronal death. These …