Lacunar infarcts and vascular dementia are important phenotypic characteristics of cerebral
autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, the …

Loss of arterial smooth muscle cells (SMCs) and abnormal accumulation of the extracellular
domain of the NOTCH3 receptor (Notch3ECD) are the 2 core features of CADASIL, a …

Acute myocardial infarction (MI), despite significant progress in its treatment, remains a
leading cause of chronic heart failure and cardiovascular events such as cardiac arrest …

Introduction Cerebral autosomal‐dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is a relatively common cerebral small vessel disease …

Functional hyperemia—activity-dependent increases in local blood perfusion—underlies the
on-demand delivery of blood to regions of enhanced neuronal activity, a process that is …

Monogenic diseases are primarily caused by mutations in a single gene; thus, they are
commonly recognized as genetic disorders with the simplest mechanisms. However, recent …

We studied small vessel disease (SVD) pathology in Familial Alzheimer's disease (FAD)
subjects carrying the presenilin 1 (PSEN1) p. Glu280Ala mutation in comparison to those …

The Notch signaling pathway is a highly versatile and evolutionarily conserved mechanism
with an important role in cell fate determination. Notch signaling plays a vital role in vascular …

Objective Heterozygous NOTCH3 variants are known to cause cerebral autosomal dominant
arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), with patients …

The neurovascular unit (NVU) is a highly organized multicellular system localized in the
brain, formed by neuronal, glial (astrocytes, oligodendrocytes, and microglia) and vascular …