Ischaemic preconditioning was originally described in animal hearts as histological infarct-
size limitation by a previous brief episode of ischaemia. In humans, ischaemic …

Methylxanthines, such as theophylline, have been used to treat cardiorespiratory disorders,
whereas caffeine is the most widely consumed psychoactive agent in various soft drinks …

Background Ticagrelor is a reversibly binding, direct-acting, oral, P 2 Y 12 antagonist used
for the prevention of atherothrombotic events in patients with coronary artery disease (CAD) …

Corticotrophin releasing factor, vasopressin, oxytocin, natriuretic hormones, angiotensin,
neuregulins, some purinergic substances, and some cytokines contribute to the long-term …

Adenosine is released in large amounts during myocardial ischemia and is capable of
exerting potent cardioprotective effects in the heart. Although these observations on …

Methods Seventeen consecutive patients with stable angina caused by a significant stenosis
of the left anterior descending (LAD) artery, who admitted into Ishinkai Yao General Hospital …

Protection from preconditioning (PC) wanes and is eventually lost when multiple bouts of
short ischemia or a prolonged reperfusion interval precedes the following sustained …

Cardiac dysfunction due to ischemia–reperfusion (I/R) is associated with marked changes in
membrane function and subsequent Ca2+-handling abnormalities in cardiomyocytes. The …

The concept of myocardial ischemic 'preconditioning' protection;(ii) summarize, for each of
these multiple (PC) has been with us since 1986 [1]. A tremendous body scenarios, the …

Myocardium has the innate potential to adapt to transient sublethal ischaemia so that it
becomes more resistant to a subsequent, more severe, ischaemic insult. The response is …