Nicorandil, a hybrid nitrate and ATP-sensitive potassium channel opener, has had a
preconditioning effect in some coronary angioplasty studies. The present study investigated …

Aims: Endogenous adenosine is considered a prominent pain mediator in ischaemia. In
contrast, it has been shown that exogenous adenosine can reduce tourniquet induced …

A variety of experimental studies have confirmed that preconditioning the myocardium by
brief periods of ischemia represents a powerful cardioprotective effect resulting in a …

OBJECTIVES This study examined the roles of myocardial perfusion and adenosine in warm-
up angina. BACKGROUND In warm-up angina, neither the role of an adenosine-mediated …

H. Thomas Lee, MD, PhD p ROLONGED and sustained ischemia produces cell death and
tissue infarction in all organ systems. Originally, the dogma was that only prompt reperfusion …

Purpose. Ischemic preconditioning (IP) protects the retina from the damaging effect of
subsequent ischemia in vivo. We aimed to investigate the histological alterations induced by …

Nicorandil has been reported to have a preconditioning effect which suppresses the ST-
segment shift or lactate production during coronary angioplasty in patients with stable …

BACKGROUND: Elaboration of a number of bioactive substances, including adenosine,
occurs in heart failure (HF). Adenosine, through the adenosine subtype 1 (A 1) receptor, can …

OBJECTIVES The aim of this study was to assess whether endogenous accumulation of
adenosine, induced by low-dose dipyridamole infusion, protects from exercise-induced …

ISCHEMIC PRECONDITIONING: CLINICAL OBSERVATIONS AND APPLICATIONS
Coronary artery disease. Strategies to exploit the endogenous protective nature of ischemic …