BamifyllineHCl is a drug of the xanthine chemical class used in asthma and Chronic
Obstructive Pulmonary Disease (COPD). It acts as a selective adenosine A1 receptor …

Der Herzinfarkt ist mit 7% eine der häufigsten Todesursachen in Deutschland. Die
Dunkelziffer ist groß. In den letzten Jahren ist die Sterblichkeit am Herzinfarkt jedoch …

BACKGROUND Already in 1929 it was recognized that adenosine, the nucleoside base of
the high energy molecule adenosine triphosphate (ATP), can serve as an extracellular …

It is evident that cardiac dysfunction due to ischemia reperfusion is associated with marked
changes in membranes and subsequent Ca 2+-handling abnormalities in cardiomy-ocytes …

The purine nucleoside adenosine appears to exert similar cardiovascular effects in humans
as it does in most laboratory animal species. These include coronary and systemic …

Recent breakthroughs in our understanding of the endogenous defense mechanisms of the
heart to ischemia have made it possible to develop novel and efficacious therapeutics for …

ABSTRACT A simple, precise, cost effective, accurate UV-spectrophotometric method has
been developed for the estimation of bamifylline hydrochloride in the Pharmaceutical …

Perioperative myocardial ischemia and dysfunction re-main prevalent after cardiac surgery
despite the use of conventional measures to provide myocardial protec-tion. Myocardial …

Homology modeling, molecular docking and molecular dynamics (MD) simulation methods
were used to build a reliable model for A1AR (as one of the G protein-coupled receptors …

It is well known that myocardial ischemia–reperfusion (IR) results in contractile dysfunction
due to Ca 2+-handling abnormalities in cardiomyocytes; these defects are primarily due to …