[HTML][HTML] Functional and structural investigation of a broadly neutralizing SARS-CoV-2 antibody

YH Chang, MF Hsu, WN Chen, MH Wu, WL Kong… - JCI insight, 2024 - ncbi.nlm.nih.gov
Since its emergence, SARS-CoV-2 has been continuously evolving, hampering the
effectiveness of current vaccines against COVID-19. mAbs can be used to treat patients at …

[HTML][HTML] Casirivimab+ imdevimab accelerates symptom resolution linked to improved COVID-19 outcomes across susceptible antibody and risk profiles

D Li, M Xu, AT Hooper, D Rofail, KA Mohammadi… - Scientific Reports, 2023 - nature.com
Severe, protracted symptoms are associated with poor outcomes in severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection. In a placebo-controlled study of …

[HTML][HTML] Antiviral activities of sotrovimab against BQ. 1.1 and XBB. 1.5 in sera of treated patients

T Bruel, LL Vrignaud, F Porrot, I Staropoli, D Planas… - medRxiv, 2023 - ncbi.nlm.nih.gov
Background Monoclonal antibodies (mAbs) targeting the spike of SARS-CoV-2 prevent
severe COVID-19. Omicron subvariants BQ. 1.1 and XBB. 1.5 evade neutralization of …

[HTML][HTML] Functional characteristics of serum Anti-SARS-CoV-2 antibodies against Delta and Omicron variants after vaccination with Sputnik V

EI Radion, VE Mukhin, AV Kholodova, IS Vladimirov… - Viruses, 2023 - mdpi.com
Anti-SARS-CoV-2 vaccination leads to the production of neutralizing as well as non-
neutralizing antibodies. In the current study, we investigated the temporal dynamics of both …

[HTML][HTML] Functional antibody responses targeting the Spike protein of SARS-CoV-2 Omicron XBB. 1.5 in elderly nursing home residents following Wuhan-Hu-1-based …

Á Sánchez-Simarro, D Fernández-Soto, B Grau… - Scientific Reports, 2024 - nature.com
The immune effector mechanisms involved in protecting against severe COVID-19 infection
in elderly nursing home residents following vaccination or natural infection are not well …

[HTML][HTML] Recent Advances in the Development of Monoclonal Antibodies and Next-Generation Antibodies

R Singh, P Chandley, S Rohatgi - ImmunoHorizons, 2023 - journals.aai.org
Abstract mAbs are highly indispensable tools for diagnostic, prophylactic, and therapeutic
applications. The first technique, hybridoma technology, was based on fusion of B …

[HTML][HTML] Therapeutic antibodies and alternative formats against SARS-CoV-2

RR Winiger, L Perez - Antiviral Research, 2024 - Elsevier
The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) heavily burdened the entire world. Despite a prompt generation of vaccines …

Systems biology of B cells in COVID-19

MC Woodruff, CE Faliti, I Sanz - Seminars in Immunology, 2024 - Elsevier
The integration of multi-'omic datasets into complex systems-wide assessments has become
a mainstay in immunologic investigation. This focus on high-dimensional data collection and …

SARS-CoV-2 spike-FLIPr fusion protein plus lipidated FLIPr protects against various SARS-CoV-2 variants in hamsters

MS Hsieh, CW Hsu, HC Liao, CL Lin… - Journal of …, 2024 - Am Soc Microbiol
Vaccine-induced mucosal immunity and broad protective capacity against various severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants remain inadequate …

[HTML][HTML] Current and future use of antibody-based passive immunity to prevent or control HBV/HDV infections.

AJ Gehring, L Salimzadeh - Antiviral Research, 2024 - Elsevier
With the increasing momentum and success of monoclonal antibody therapy in conventional
medical practices, there is a revived emphasis on the development of monoclonal …