BACKGROUND The many manipulations and processes used in ART coincide with the
timing of epigenetic reprogramming and imprinting during female gametogenesis and pre …

Epigenetic alterations are associated with normal biological processes such as aging or
differentiation. Changes in global epigenetic signatures, together with genetic alterations …

Motivation The rapid development of spatial transcriptomics (ST) approaches has provided
new insights into understanding tissue architecture and function. However, the gene …

Background Accurate CNS tumor diagnosis can be challenging, and methylation profiling
can serve as an adjunct to classify diagnostically difficult cases. Methods An integrated …

Simple Summary Phenotypic plasticity, the genome producing multiple phenotypes, is
central to an animal's ability to respond to environmental change, expected or otherwise. A …

Methylation of cytosine residues in DNA, the best studied epigenetic modification, is
associated with gene transcription and nuclear organization, and ultimately the function of a …

Alzheimer's disease (AD) is the most common cause of dementia with advancing age as its
strongest risk factor. AD neuropathologic change (ADNC) is known to be associated with …

Microarray technology has been used to measure genome-wide DNA methylation in
thousands of individuals. These studies typically test the associations between individual …

When assessed over a large number of samples, bulk RNA sequencing provides reliable
data for gene expression at the tissue level. Single-cell RNA sequencing (scRNA-seq) …

Human bulk tissue samples comprise multiple cell types with diverse roles in disease
etiology. Conventional transcriptome-wide association study approaches predict genetically …