Objective We undertook this study to estimate changes in cell‐specific DNA methylation
(DNAm) associated with methotrexate (MTX) response using whole blood samples collected …

Drug development (target identification, advancing drug leads to candidates for preclinical
and clinical studies) can be facilitated by genetic and genomic knowledge. Here, we review …

The majority of epigenetic epidemiology studies to date have generated genome-wide
profiles from bulk tissues (eg, whole blood) however these are vulnerable to confounding …

Tumor tissue engineering holds great promise for replicating the physiological and
behavioral characteristics of tumors in vitro. Advances in this field have led to new …

Congenital diaphragmatic hernia (CDH) is a congenital structural anomaly in which the
diaphragm has not developed properly. It may occur either as an isolated anomaly or with …

Lymphoid neoplasms represent a heterogeneous group of disease entities and subtypes
with markedly different molecular and clinical features. Beyond genetic alterations, lymphoid …

Accounting for cell type compositions has been very successful at analyzing high-throughput
data from heterogeneous tissues. Differential gene expression analysis at cell type level is …

Epigenetics studies inheritable and reversible modifications of DNA that allow cells to
control gene expression throughout their development and in response to environmental …

Microarray technology has been used to measure genome-wide DNA methylation in
thousands of individuals. These studies typically test the associations between individual …

DNA methylation profiling offers unique insights into human development and diseases.
Often the analysis of complex tissues and cell mixtures is the only feasible option to study …