Genetic variation and epigenetic factors are thought to contribute to the development of
hypersensitivity to aspirin. DNA methylation fluctuates dynamically throughout the day. To …

Understanding the dynamic expression of proteins and other key molecules driving
phenotypic remodeling in development and pathobiology has garnered widespread interest …

Cell-free DNA (cfDNA) from the bloodstream has been studied for cancer biomarker
discovery, and chromatin-derived epigenetic features have come into the spotlight for their …

Background Epigenome-wide association studies using peripheral blood have identified
specific sites of DNA methylation associated with risk of various cancers and may hold …

Abstract 22q11. 2 reciprocal copy number variants (CNVs) offer a powerful quasi-
experimental “reverse-genetics” paradigm to elucidate how gene dosage (ie, deletions and …

Transfer RNAs (tRNAs) are the most heavily modified RNA species in life entities. Post-
transcriptional modifications severely impact the structure and function of tRNAs. To date …

Epigenome-wide mediation analysis aims to identify DNA methylation CpG sites that
mediate the causal effects of genetic/environmental exposures on health outcomes …

In higher plants, pluripotent stem cells reside in the specialized microenvironment called
stem cell niches (SCNs) harbored at the shoot apical meristem (SAM) and root apical …

We have developed the regional principal components (rPCs) method, a novel approach for
summarizing gene-level methylation. rPCs address the challenge of deciphering complex …

Many DNA methylation (DNAm) data are from tissues composed of various cell types, and
hence cell deconvolution methods are needed to infer their cell compositions accurately …