Background: This systematic review summarizes the impact of pharmacogenetics on the
effect and safety of non-steroidal anti-inflammatory drugs (NSAIDs) and antidepressants …

Pain is a cardinal feature of many diseases. Chronic pain poses heavy burdens to the
suffering patients, both physically and mentally. However, current mainstream medications …

Cytochrome P-450 (CYP) enzymes have a key role in the metabolism of xenobiotics of food
origin, and their highly polymorphic nature concurs with the diverse inter-individual …

The last 2 decades have witnessed dramatic swings in the perioperative use of analgesic
medications. The concept of pain as the fifth vital sign and regulatory emphasis on adequate …

This review emphasises the importance of opioid monitoring in clinical practice and
advocates for a personalised approach based on pharmacogenetics. Beyond effectively …

Opioids are an important therapeutic option for severe resistant chronic pain but, in the
absence of proper oversight, their use has risks. The level of prescription opioid …

There has been a worldwide substantial increase in accidental opioid-overdose deaths. The
aim of this review, along with preliminary results from our pilot study, is to highlight the use of …

Allogeneic hematopoietic stem cell transplantation mortality has declined over the years,
though prevention and management of treatment-related toxicities and post-transplant …

Despite complex pathways of drug disposition, clinical pharmacogenetic predictors currently
rely on only a few high effect variants. Quantification of the polygenic contribution to …

Pharmacogenetics (PGx) has the potential to improve opioid medication management. Here,
we present patient perception data, pharmacogenetic data and medication management …