Pathophysiological mechanisms leading to muscle loss in chronic kidney disease

XH Wang, WE Mitch, SR Price - Nature Reviews Nephrology, 2022 - nature.com
Loss of muscle proteins is a deleterious consequence of chronic kidney disease (CKD) that
causes a decrease in muscle strength and function, and can lead to a reduction in quality of …

Dietary protein intake and chronic kidney disease

GJ Ko, Y Obi, AR Tortorici… - Current Opinion in …, 2017 - journals.lww.com
Dietary protein intake and chronic kidney disease : Current Opinion in Clinical Nutrition &
Metabolic Care Dietary protein intake and chronic kidney disease : Current Opinion in Clinical …

Weight loss, malnutrition, and cachexia in COVID‐19: facts and numbers

MS Anker, U Landmesser… - Journal of cachexia …, 2021 - Wiley Online Library
Patients with COVID‐19 disease are prone to develop significant weight loss and clinical
cachexia. Three reports with altogether 589 patients that reported on weight loss and …

PTH/PTHrP receptor mediates cachexia in models of kidney failure and cancer

S Kir, H Komaba, AP Garcia, KP Economopoulos… - Cell metabolism, 2016 - cell.com
Cachexia is a wasting syndrome associated with elevated basal energy expenditure and
loss of adipose and muscle tissues. It accompanies many chronic diseases including renal …

[HTML][HTML] Management of protein-energy wasting in non-dialysis-dependent chronic kidney disease: reconciling low protein intake with nutritional therapy

CP Kovesdy, JD Kopple, K Kalantar-Zadeh - The American journal of …, 2013 - Elsevier
ABSTRACT Protein-energy wasting (PEW), characterized by a decline in body protein mass
and energy reserves, including muscle and fat wasting and visceral protein pool contraction …

Role of oxidative stress as key regulator of muscle wasting during cachexia

J Ábrigo, AA Elorza, CA Riedel, C Vilos… - Oxidative medicine …, 2018 - Wiley Online Library
Skeletal muscle atrophy is a pathological condition mainly characterized by a loss of
muscular mass and the contractile capacity of the skeletal muscle as a consequence of …

A prospective study of frailty in nephrology-referred patients with CKD

B Roshanravan, M Khatri, C Robinson-Cohen… - American Journal of …, 2012 - Elsevier
BACKGROUND: Frailty is a construct developed to characterize a state of reduced functional
capacity in older adults. However, there are limited data describing the prevalence or …

Myostatin/activin pathway antagonism: molecular basis and therapeutic potential

HQ Han, X Zhou, WE Mitch, AL Goldberg - The international journal of …, 2013 - Elsevier
Muscle wasting is associated with a wide range of catabolic diseases. This debilitating loss
of muscle mass and functional capacity reduces the quality of life and increases the risks of …

Effects of hormonal changes on sarcopenia in chronic kidney disease: where are we now and what can we do?

O Gungor, S Ulu, NB Hasbal, SD Anker… - Journal of cachexia …, 2021 - Wiley Online Library
Sarcopenia or muscle wasting is a progressive and generalized skeletal muscle disorder
involving the accelerated loss of muscle mass and function, often associated with muscle …

Muscle wasting in end-stage renal disease promulgates premature death: established, emerging and potential novel treatment strategies

P Stenvinkel, JJ Carrero, F Von Walden… - Nephrology Dialysis …, 2016 - academic.oup.com
Muscle wasting (or sarcopenia) is a common feature of the uremic phenotype and
predisposes this vulnerable patient population to increased risk of comorbid complications …