The genetic diagnosis of patients with seizure disorders has been improved significantly by
the development of affordable next-generation sequencing technologies. Indeed, in the last …

High-throughput behavioral phenotyping is critical to genetic or chemical screening
approaches. Zebrafish larvae are amenable to high-throughput behavioral screening …

Recent advances in psychiatric genetics have led to the discovery of dozens of genomic loci
associated with schizophrenia. However, a gap exists between the detection of genetic …

The unique combination of small size, translucency, and powerful genetic tools makes larval
zebrafish a uniquely useful vertebrate system to investigate normal and pathological brain …

Learning is essential for animal survival under changing environments. Even in its simplest
form, learning involves interactions between a handful of neuronal circuits, hundreds of …

Schizophrenia remains one of the most debilitating human neurodevelopmental disorders,
with few effective treatments and striking consequences felt by individuals, communities and …

Human developmental disorders encompass a wide range of debilitating physical
conditions and intellectual disabilities. Perturbation of protein kinase signalling underlies the …

Mental health disorders are a leading cause of disability worldwide. Challenges such as
disease heterogeneity, incomplete characterization of the targets of existing drugs and a …

Genome-wide association studies (GWASs) have reported multiple single nucleotide
polymorphisms (SNPs) associated with schizophrenia, yet the underlying molecular …

Broad-based cognitive deficits are an enduring and disabling symptom for many patients
with severe mental illness, and these impairments are inadequately addressed by current …