Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants

M Moriyama, C Lucas, VS Monteiro… - Proceedings of the …, 2023 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs)
possess mutations that confer resistance to neutralizing antibodies within the Spike protein …

SARS-CoV-2 ORF8 as a modulator of cytokine induction: evidence and search for molecular mechanisms

MI Móvio, GWC Almeida, IGL Martines… - Viruses, 2024 - mdpi.com
Severe cases of SARS-CoV-2 infection are characterized by an immune response that leads
to the overproduction of pro-inflammatory cytokines, resulting in lung damage …

Myeloid dysregulation and therapeutic intervention in COVID-19

R Gu, T Mao, Q Lu, TT Su, J Wang - Seminars in immunology, 2021 - Elsevier
The dysregulation of myeloid cell responses is increasingly demonstrated to be a major
mechanism of pathogenesis for COVID-19. The pathological cellular and cytokine …

Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection

X Lin, B Fu, Y Xiong, N Xing, W Xue, D Guo… - PLoS …, 2023 - journals.plos.org
Coronavirus disease 2019 is a respiratory infectious disease caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidence on the pathogenesis of SARS …

SARS-CoV-2 Omicron subvariants evolved to promote further escape from MHC-I recognition

M Moriyama, C Lucas, VS Monteiro… - bioRxiv, 2022 - biorxiv.org
SARS-CoV-2 variants of concern (VOCs) possess mutations that confer resistance to
neutralizing antibodies within the Spike protein and are associated with breakthrough …

The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm

M Hamdorf, T Imhof, B Bailey-Elkin… - Journal of Molecular …, 2023 - academic.oup.com
The novel coronavirus pandemic, first reported in December 2019, was caused by the
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infection …