Deconstructing virus condensation

N Lopez, G Camporeale, M Salgueiro… - PLoS …, 2021 - journals.plos.org
Viruses have evolved precise mechanisms for using the cellular physiological pathways for
their perpetuation. These virus-driven biochemical events must be separated in space and …

Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection

P Chen, M Wu, Y He, B Jiang, ML He - Signal Transduction and …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2
infection has become a global pandemic due to the high viral transmissibility and …

Identification of a negative-strand RNA virus with natural plant and fungal hosts

R Dai, S Yang, T Pang, M Tian… - Proceedings of the …, 2024 - National Acad Sciences
The presence of viruses that spread to both plant and fungal populations in nature has
posed intriguingly scientific question. We found a negative-strand RNA virus related to …

The CYTOLD and ERTOLD pathways for lipid droplet–protein targeting

MJ Olarte, JMJ Swanson, TC Walther… - Trends in biochemical …, 2022 - cell.com
Lipid droplets (LDs) are the main organelles for lipid storage, and their surfaces contain
unique proteins with diverse functions, including those that facilitate the deposition and …

Interplay between lipid metabolism, lipid droplets, and DNA virus infections

MA Farías, B Diethelm-Varela, AJ Navarro, AM Kalergis… - Cells, 2022 - mdpi.com
Lipid droplets (LDs) are cellular organelles rich in neutral lipids such as triglycerides and
cholesterol esters that are coated by a phospholipid monolayer and associated proteins …

An overview of the role of Niemann-pick C1 (NPC1) in viral infections and inhibition of viral infections through NPC1 inhibitor

I Ahmad, SN Fatemi, M Ghaheri, A Rezvani… - Cell Communication and …, 2023 - Springer
Viruses communicate with their hosts through interactions with proteins, lipids, and
carbohydrate moieties on the plasma membrane (PM), often resulting in viral absorption via …

Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus

YB Baek, HJ Kwon, M Sharif, J Lim, IC Lee… - … and Targeted Therapy, 2022 - nature.com
The biosynthesis of host lipids and/or lipid droplets (LDs) has been studied extensively as a
putative therapeutic target in diverse viral infections. However, directly targeting the LD …

Potential use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition and prevention method in viral infection

K Muzammil, MH Hooshiar, S Varmazyar… - Microbial Cell …, 2024 - Springer
Cellular lipid membranes serve as the primary barrier preventing viral infection of the host
cell and provide viruses with a critical initial point of contact. Occasionally, viruses can utilize …

Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications

R Rakotonirina-Ricquebourg, V Costa… - Progress in Lipid …, 2022 - Elsevier
Lipid droplets (LDs) are ubiquitous organelles that play crucial roles in response to
physiological and environmental cues. The identification of several neutral lipid synthesizing …

Lipid droplets and the host–pathogen dynamic: FATal attraction?

M Bosch, MJ Sweet, RG Parton, A Pol - Journal of Cell Biology, 2021 - rupress.org
In the ongoing conflict between eukaryotic cells and pathogens, lipid droplets (LDs) emerge
as a choke point in the battle for nutrients. While many pathogens seek the lipids stored in …