Marine natural products

JW Blunt, BR Copp, RA Keyzers, MHG Munro… - Natural Product …, 2015 - pubs.rsc.org
Covering: 2013. Previous review: Nat. Prod. Rep., 2014, 31, 160–258 This review covers the
literature published in 2013 for marine natural products (MNPs), with 982 citations (644 for …

Antiplasmodial natural products: an update

N Tajuddeen, FR Van Heerden - Malaria journal, 2019 - Springer
Background Malaria remains a significant public health challenge in regions of the world
where it is endemic. An unprecedented decline in malaria incidences was recorded during …

Potential of marine natural products against drug-resistant fungal, viral, and parasitic infections

UR Abdelmohsen, S Balasubramanian… - The Lancet Infectious …, 2017 - thelancet.com
Antibiotics have revolutionised medicine in many aspects, and their discovery is considered
a turning point in human history. However, the most serious consequence of the use of …

Marine pharmacology in 2012–2013: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral …

AMS Mayer, AD Rodríguez, O Taglialatela-Scafati… - Marine drugs, 2017 - mdpi.com
The peer-reviewed marine pharmacology literature from 2012 to 2013 was systematically
reviewed, consistent with the 1998–2011 reviews of this series. Marine pharmacology …

Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning

LN Alberca, ML Sbaraglini, D Balcazar… - Journal of computer …, 2016 - Springer
Chagas disease is a parasitic infection caused by the protozoa Trypanosoma cruzi that
affects about 6 million people in Latin America. Despite its sanitary importance, there are …

Isolation and Synthesis of Pulmonarins A and B, Acetylcholinesterase Inhibitors from the Colonial Ascidian Synoicum pulmonaria

M Tadesse, J Svenson, K Sepčić… - Journal of natural …, 2014 - ACS Publications
Pulmonarins A and B are two new dibrominated marine acetylcholinesterase inhibitors that
were isolated and characterized from the sub-Arctic ascidian Synoicum pulmonaria …

Synthesis and antimalarial evaluation of artesunate-polyamine and trioxolane-polyamine conjugates

AN Pearce, M Kaiser, BR Copp - European journal of medicinal chemistry, 2017 - Elsevier
A series of artesunate-polyamine and trioxolane-polyamine conjugates have been
prepared. The conjugates were evaluated for antimalarial activity towards the K1 dual drug …

A combined ligand and target-based virtual screening strategy to repurpose drugs as putrescine uptake inhibitors with trypanocidal activity

MA Llanos, LN Alberca, MD Ruiz, ML Sbaraglini… - Journal of Computer …, 2023 - Springer
Chagas disease, also known as American trypanosomiasis, is a neglected tropical disease
caused by the protozoa Trypanosoma cruzi, affecting nearly 7 million people only in the …

Valorisation of the diterpene podocarpic acid–Antibiotic and antibiotic enhancing activities of polyamine conjugates

SA Li, MM Cadelis, RC Deed, H Douafer… - Bioorganic & Medicinal …, 2022 - Elsevier
As part of our search for new antimicrobials and antibiotic adjuvants, a series of podocarpic
acid-polyamine conjugates have been synthesized. The library of compounds made use of …

Interrogating alkyl and arylalkylpolyamino (bis) urea and (bis) thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium …

BK Verlinden, M De Beer, B Pachaiyappan… - Bioorganic & medicinal …, 2015 - Elsevier
A new series of potent potent aryl/alkylated (bis) urea-and (bis) thiourea polyamine
analogues were synthesized and evaluated in vitro for their antiplasmodial activity. Altering …