[HTML][HTML] Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19

LYR Wong, J Zheng, K Wilhelmsen, K Li, ME Ortiz… - Nature, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is especially severe in aged populations.
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are …

[HTML][HTML] Inflammation in COVID-19: from pathogenesis to treatment

RSY Wong - International journal of clinical and experimental …, 2021 - ncbi.nlm.nih.gov
Abstract The coronavirus disease 2019 (COVID-19) was declared a pandemic in March
2020 by the World Health Organization (WHO). To date, there were> 163 million confirmed …

Results of the CAPSID randomized trial for high-dose convalescent plasma in patients with severe COVID-19

S Körper, M Weiss, D Zickler… - The Journal of …, 2021 - Am Soc Clin Investig
BACKGROUND COVID-19 convalescent plasma (CCP) has been considered a treatment
option for COVID-19. This trial assessed the efficacy of a neutralizing antibody containing …

The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection

MS Qudus, M Tian, S Sirajuddin, S Liu… - Journal of Medical …, 2023 - Wiley Online Library
In patients with severe COVID‐19, acute respiratory distress syndrome (ARDS), multiple
organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm …

Clinical characteristics and outcomes of immunocompromised patients with coronavirus disease 2019 caused by the omicron variant: a prospective, observational …

SRK Malahe, RAS Hoek, VASH Dalm… - Clinical Infectious …, 2023 - academic.oup.com
Background Illness after infection with the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) Omicron variant is less severe compared with previous variants. Data on the …

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

O Abani, A Abbas, F Abbas, M Abbas, S Abbasi… - The Lancet, 2021 - thelancet.com
Background Many patients with COVID-19 have been treated with plasma containing anti-
SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent …

Factors associated with mortality in patients with COVID‐19 admitted to intensive care: a systematic review and meta‐analysis

EH Taylor, EJ Marson, M Elhadi, KDM Macleod… - …, 2021 - Wiley Online Library
Identification of high‐risk patients admitted to intensive care with COVID‐19 may inform
management strategies. The objective of this meta‐analysis was to determine factors …

Immunosenescence, inflammaging, and frailty: role of myeloid cells in age-related diseases

A Bleve, F Motta, B Durante, C Pandolfo… - Clinical reviews in …, 2022 - Springer
The immune system is the central regulator of tissue homeostasis, ensuring tissue
regeneration and protection against both pathogens and the neoformation of cancer cells. Its …

Tixagevimab–cilgavimab for treatment of patients hospitalised with COVID-19: a randomised, double-blind, phase 3 trial

TL Holland, AA Ginde, R Paredes… - The Lancet …, 2022 - thelancet.com
Background Tixagevimab–cilgavimab is a neutralising monoclonal antibody combination
hypothesised to improve outcomes for patients hospitalised with COVID-19. We aimed to …

Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study

JP Gangneux, E Dannaoui, A Fekkar… - The Lancet …, 2022 - thelancet.com
Background Patients with severe COVID-19 have emerged as a population at high risk of
invasive fungal infections (IFIs). However, to our knowledge, the prevalence of IFIs has not …