Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …

RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

Despite tumor-associated macrophages (TAMs) playing a key role in shaping the tumor
microenvironment (TME), the mechanisms by which TAMs influence the TME and contribute …

Dysregulation of the Notch signaling pathway, which is highly conserved across species,
can drive aberrant epigenetic modification, transcription, and translation. Defective gene …

Abstract Divergent N6-methyladenosine (m6A) modifications are dynamic and reversible
posttranscriptional RNA modifications that are mediated by m6A regulators or m6A RNA …

Cancer drug resistance represents the main obstacle in cancer treatment. Drug-resistant
cancers exhibit complex molecular mechanisms to hit back therapy under pharmacological …

Abstract N6-methyladenosine (m6A) methylation is the most universal internal modification
in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and …

The tumor microenvironment (TME), which is regulated by intrinsic oncogenic mechanisms
and epigenetic modifications, has become a research hotspot in recent years. Characteristic …

Abstract Background N4-acetylcytidine (ac4C) as a significant RNA modification has been
reported to maintain the stability of mRNA and to regulate the translation process. However …

N6-Methyladenosine (m6A) demethylases can catalyze the removal of the methyl
modification on m6A, and it is closely associated with the occurrence, proliferation …