Examining the shared etiology of psychopathology with genome-wide association studies
TT Mallard, AD Grotzinger… - Physiological …, 2023 - journals.physiology.org
Genome-wide association studies (GWASs) have ushered in a new era of reproducible
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …
than most other psychiatric disorders. The contribution to biological understanding from …
Precision psychiatry: predicting predictability
E van Dellen - Psychological Medicine, 2024 - cambridge.org
Precision psychiatry is an emerging field that aims to provide individualized approaches to
mental health care. An important strategy to achieve this precision is to reduce uncertainty …
mental health care. An important strategy to achieve this precision is to reduce uncertainty …
Metabolome subtyping reveals multi-omics characteristics and biological heterogeneity in major psychiatric disorders
Growing evidence suggests that major psychiatric disorders (MPDs) share common
etiologies and pathological processes. However, the diagnosis is currently based on …
etiologies and pathological processes. However, the diagnosis is currently based on …
Large-scale whole-exome sequencing of neuropsychiatric diseases and traits in 350,770 adults
YT Deng, BS Wu, L Yang, XY He, JJ Kang… - Nature Human …, 2024 - nature.com
While numerous genomic loci have been identified for neuropsychiatric conditions, the
contribution of protein-coding variants has yet to be determined. Here we conducted a large …
contribution of protein-coding variants has yet to be determined. Here we conducted a large …
Cross-phenotype relationship between opioid use disorder and suicide attempts: new evidence from polygenic association and Mendelian randomization analyses
Y Huang, D Chen, AM Levin, BK Ahmedani… - Molecular …, 2023 - nature.com
Clinical epidemiological studies have found high co-occurrence between suicide attempts
(SA) and opioid use disorder (OUD). However, the patterns of correlation and causation …
(SA) and opioid use disorder (OUD). However, the patterns of correlation and causation …
Convergence of the dysregulated regulome in schizophrenia with polygenic risk and evolutionarily constrained enhancers
Enhancers play an essential role in the etiology of schizophrenia; however, the
dysregulation of enhancer activity and its impact on the regulome in schizophrenia remains …
dysregulation of enhancer activity and its impact on the regulome in schizophrenia remains …
Discovery of 95 PTSD loci provides insight into genetic architecture and neurobiology of trauma and stress-related disorders
Posttraumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …
than most other psychiatric disorders. The contribution to biological understanding from …
Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish models
E Antón-Galindo, MR Adel, J García-González… - Translational …, 2024 - nature.com
RBFOX1 is a highly pleiotropic gene that contributes to several psychiatric and
neurodevelopmental disorders. Both rare and common variants in RBFOX1 have been …
neurodevelopmental disorders. Both rare and common variants in RBFOX1 have been …
Genetic network structure of 13 psychiatric disorders in the general population
Psychiatric disorders frequently co-occur and share common symptoms and genetic
backgrounds. Previous research has used genome-wide association studies to identify the …
backgrounds. Previous research has used genome-wide association studies to identify the …