Abstract Information storage and retrieval is essential for all life. In biology, information is
primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a …

With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …

Heterochronic parabiosis (HPB) is known for its functional rejuvenation effects across
several mouse tissues. However, its impact on biological age and long-term health is …

Single-cell chromatin accessibility sequencing (scATAC-seq) reconstructs developmental
trajectory by phenotypic similarity. However, inferring the exact developmental trajectory is …

Epigenetic drift or “disorder” increases across the mouse lifespan and is suggested to
underlie epigenetic clock signals. While the role of epigenetic drift in determining maximum …

Aging is a nearly inescapable trait among organisms yet lifespan varies tremendously
across different species and spans several orders of magnitude in vertebrates alone. This …

Young blood plasma is known to confer beneficial effects on various organs in mice and
rats. However, it was not known whether plasma from young adult pigs rejuvenates old rat …

To build health equity for an aging world marked by dramatic disparities in healthy lifespan
between countries, regions and population groups, research at the intersections of biology …

Aging clocks have provided one of the most important recent breakthroughs in the biology of
aging, and may provide indicators for the effectiveness of interventions in the aging process …

By analyzing 15,000 samples from 348 mammalian species, we derive DNA methylation
(DNAm) predictors of maximum life span (R= 0.89), gestation time (R= 0.96), and age at …