Metallo beta-lactamase (MBL) producing Pseudomonas aeruginosa is an emerging threat
and a cause of concern for the physicians treating such infections. The present study was …

The crystal structure of the class-B β-lactamase, BlaB, from the pathogenic bacterium,
Chryseobacterium meningosepticum, in complex with the inhibitor, d-captopril, has been …

Bacterial resistance is compromising the use of β-lactam antibiotics including carbapenems.
The main resistance mechanism against β-lactams is hydrolysis of the β-lactam ring …

A number of captopril analogues were synthesised and tested as inhibitors of the metallo-β-
lactamase IMP-1. Structure–activity studies showed that the methyl group was unimportant …

Abstract β-Lactamases are hydrolytic enzymes capable of opening the β-lactam ring of
antibiotics such as penicillin, thus endowing the bacteria that produce them with antibiotic …

Drug-resistant pathogens pose a global challenge to public health as they cause diseases
that are extremely difficult to cure. Metallo-β-lactamases (MBLs) are a diverse set of zinc …

The β-lactam antibiotics are essential for the treatment of a wide range of human bacterial
diseases. However, a class of zinc-dependent hydrolases known as the metallo-β …

There are currently no clinically available inhibitors of metallo-β-lactamases (MBLs). These
enzymes confer resistance to bacteria against a broad range of commonly used β-lactam …

Pathogenic bacteria that produce metallo-b-lactamases (MBLs) are emerging as a new
challenge to the medical community. These enzymes catalyze the hydrolysis of a wide …

Thiol dioxygenation is the initial oxidation step that commits a thiol to important catabolic or
biosynthetic pathways. The reaction is catalyzed by a family of specific non-heme …