During the past few years the results from molecular biological, biochemical, chemical,
physical and theoretical approaches expanded the knowledge about metallo-β-lactamases …

ABSTRACT A novel subclass B3 metallo-β-lactamase (MBL), SMB-1, recently identified from
a Serratia marcescens clinical isolate, showed a higher hydrolytic activity against a wide …

The inhibitory effect of a variety of thiol compounds on the function of binuclear metallo-β-
lactamases, with a particular focus on IMP-1 from Pseudomonas aeruginosa, has been …

Metallo-β-lactamase IMP-1 is a di-Zn (II) metalloenzyme that efficiently hydrolyzes β-lactam
antibiotics. Wild-type (WT) IMP-1 has a conserved Asp-120 (81) in the active site, which …

The mononuclear zinc thiolate complexes [(TpPhMe) Zn (SR)], where TpPhMe is hydrotris
((3-methyl-5-phenyl) pyrazolyl) borate and (SR) is benzyl thiolate, 4-nitrophenylthiolate, 4 …

Binuclear metallohydrolases are a family of proteins that can be targeted for drug discovery.
The common feature of these enzymes is the presence of two closely spaced metal ions (ie …

SYNTHESIS AND SAR OF THIOESTER AND THIOL INHIBITORS OF IMP-1 METALLO-~-LACTAMASE
Page 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Pergamon Bioorganic & Medicinal …

Carbonic anhydrases (CAs), because they catalyze the interconversion of carbon dioxide
(CO2) and water into bicarbonate (HCO3−) and protons (H+), thereby influencing pH, are …

Gram-negative bacteria producing metallo-β-lactamases (MBLs) have become a
considerable threat to public health. MBLs including the IMP, VIM, and NDM types are Zn (II) …

Resistance to carbapenem antibiotics in Gram-negative bacteria is due, in part, to
expression of a wide spectrum metallo-β-lactamase, which renders the drug inactive …