The dynamics of the IMP-1 enzyme complexed with three prototypical inhibitors are
investigated using a quantum mechanical/molecular mechanical (QM/MM) method based on …

The emergence of drug-resistant pathogenic bacteria is occurring due to the global overuse
and misuse of β-lactam antibiotics. Infections caused by some bacteria which secrete …

Clinical utilization of carbapenems remains under threat with the emergence of acquired
carbapenemase-producing bacteria, particularly metallo-β-lactamases (MBL). Rapid …

目的通过比较氯化铜(CuCl2), 氯化铁(FeCl3), 乙二胺四乙酸(EDTA), 巯基乙醇和2-
巯基丙酸五种不同化合物对金属β-内酰胺酶(metallo-β-lactamase, MBL) 的抑制作用 …

A fluorescent probe for the detection of a metallo-β-lactamase (IMP-1), N-[2-(5-
dimethylaminonaphthalen-1-ylsulfonylamino) ethyl]-3-mercaptopropionamide …

Use of imipenem resistant strains alone can reduce the screening work greatly and
imipenem with EDTA is found to give larger inhibition zones especially for VIM-2 isolates7 …

目的: 建立金属β-内酰胺酶IMP-1 的表达, 纯化和鉴定方法, 并探讨实验条件对分离纯化的影响.
方法: pET9a/d-IMP-1 质粒转化至E. coli Competent BL21 (DE3) Cell 并在LB 培养基中表达后 …

Background: The emergence of carbapenem-hydrolyzing metallo-β-lactamases (MBLs) is a
serious threat to clinical medication of carbapenems. We evaluated the contributions of IMP …

Zinc is one of the essential trace elements and the second most abundant transition metal in
biology after iron (1, 2). This element was discovered by the German chemist Andreas …

Limited β-lactams show antipseudomonal activity. The rapid spread of IMP-type metallo-β-
lactamases (MBLs), which have a broad spectrum of substrates and a poor susceptibility to …