The accumulation of misfolded alpha-synuclein (aSyn) throughout the brain, as Lewy
pathology, is a phenomenon central to Parkinson's disease (PD) pathogenesis. The …

Synucleinopathies are a group of neurodegenerative diseases characterized by the
accumulation of α-synuclein aggregates in neurons, nerve fibers or glial cells. Three main …

Neurological diseases associated with pathogenic variants in a specific gene, or even with a
specific pathogenic variant, can show profound phenotypic variation with regard to symptom …

Leucine-rich repeat kinase 2 (LRRK2) is a complex GTPase/kinase orchestrating
cytoskeletal dynamics and multiple steps of the endolysosomal pathway through interaction …

Parkinson's disease (PD) is the second most common neurodegenerative disorder in the
aging population, and no disease-modifying therapy has been approved to date. The …

Parkinson's disease (PD) is a heterogeneous neurodegenerative disease characterized by
the progressive loss of dopaminergic neurons in the substantia nigra pars compacta and the …

Leucine-rich repeat kinase 2 (LRRK2) is a large protein kinase that physiologically
phosphorylates and regulates the function of several Rab proteins. LRRK2 is genetically …

Parkinson's disease is a neurodegenerative condition initially characterized by the presence
of tremor, muscle stiffness and impaired balance, with the deposition of insoluble protein …

In 2004, the identification of pathogenic variants in the LRRK2 gene across several families
with autosomal dominant late-onset Parkinson's disease (PD) revolutionized our …

Presentation and progression of cognitive symptoms in Parkinson's disease are highly
variable. PD is a genetically complex disorder with multiple genetic risk factors and …