Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in
response to cellular damage and stress. Senescent cells (SnCs) can develop a …

Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Engineering a patient's own T cells to selectively target and eliminate tumour cells has cured
patients with untreatable haematologic cancers. These results have energized the field to …

Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

The chronic use of glucocorticoids decreases bone mass and quality and increases bone-
marrow adiposity, but the underlying mechanisms remain unclear. Here, we show that bone …

Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Cell senescence (CS) is at the nexus between aging and associated chronic disorders, and
aging increases the burden of CS in all major metabolic tissues. However, CS is also …

The role of the microbiome in human aging is important: the microbiome directly impacts
aging through the gastrointestinal system. However, the microbial impact on skin has yet to …

The prevalence of obesity and associated chronic diseases continues to increase
worldwide, negatively impacting on societies and economies. Whereas the association …