[HTML][HTML] Benzimidazole: A Versatile Scaffold for Drug Discovery and Beyond-A Comprehensive Review of Synthetic Approaches and Recent Advancements in …
ND Mahurkar, ND Gawhale, MN Lokhande, SJ Uke… - Results in …, 2023 - Elsevier
Heterocyclic compounds are foundational in drug discovery, constituting the core structure of
approximately 80% of pharmaceuticals. Benzimidazole, in particular, emerges as a critical …
approximately 80% of pharmaceuticals. Benzimidazole, in particular, emerges as a critical …
[HTML][HTML] Benzimidazole-based schiff base hybrid scaffolds: a promising approach to develop multi-target drugs for alzheimer's disease
A series of benzimidazole-based Schiff base derivatives (1–18) were synthesized and
structurally elucidated through 1H NMR, 13C NMR and HREI-MS analysis. Subsequently …
structurally elucidated through 1H NMR, 13C NMR and HREI-MS analysis. Subsequently …
Synthesis, solvent-solute interactions (polar and non-polar), spectroscopic insights, topological aspects, Fukui functions, molecular docking, ADME, and donor …
AR Kumar, S Selvaraj, GPS Mol, M Selvaraj… - Journal of Molecular …, 2024 - Elsevier
The favorite heteroatom-containing compound, 2-(trifluoromethyl) benzimidazole (2TFMBI),
was synthesized and experimentally characterized using spectroscopic techniques. Density …
was synthesized and experimentally characterized using spectroscopic techniques. Density …
Emerging Trends in Small Molecule Inhibitors Targeting Aldosterone Synthase: A New Paradigm in Cardiovascular Disease Treatment
C Guo, G Zhang, C Wu, Y Lei, Y Wang… - European Journal of …, 2024 - Elsevier
Abstract Aldosterone synthase (CYP11B2) is the rate-limiting enzyme in aldosterone
production. In recent years, CYP11B2 has become an appealing target for treating …
production. In recent years, CYP11B2 has become an appealing target for treating …
Synthesis, In Vitro Biological Evaluation and Molecular Modeling of Benzimidazole-Based Pyrrole/Piperidine Hybrids Derivatives as Potential Anti-Alzheimer Agents
Benzimidazole-based pyrrole/piperidine analogs (1–26) were synthesized and then
screened for their acetylcholinesterase and butyrylcholinesterase activities. All the analogs …
screened for their acetylcholinesterase and butyrylcholinesterase activities. All the analogs …
Environmentally friendly and efficient TBHP-mediated catalytic reaction for the synthesis of substituted benzimidazole-2-ones: In-silico approach to pharmaceutical …
M Indira, ECS Reddy, VK Prasad, VS Swamy… - Environmental …, 2024 - Elsevier
A novel method was used to synthesize benzimidazole-2-ones from the corresponding
benzimidazolium salts. These salts were subsequently reacted with potassium tertiary …
benzimidazolium salts. These salts were subsequently reacted with potassium tertiary …
Recent Advances in the Fixation of CO2 into Quinazoline and Benzimidazole
D Rajanna, PM Srinivasappa, A Sudhakaran… - Energy & …, 2024 - ACS Publications
CO2 is an important component of the atmosphere that helps in balancing the Earth's
atmospheric temperature and channelizes the food cycles. However, an increase or …
atmospheric temperature and channelizes the food cycles. However, an increase or …
[HTML][HTML] Structure-based development of 3, 5-dihydroxybenzoyl-hydrazineylidene as tyrosinase inhibitor; in vitro and in silico study
A series of new analogs of 3, 5-dihydroxybenzoyl-hydrazineylidene conjugated to different
methoxyphenyl triazole (11a-n) synthesized using click reaction. The structures of all …
methoxyphenyl triazole (11a-n) synthesized using click reaction. The structures of all …
Design, synthesis, molecular docking and biological studies of some novel pyrrolidine-triazole-aurone hybrids against digestive enzymes
Here in this work we successfully designed and synthesized a library of some novel
pyrrolidine-triazole-aurone hybrids ie (Z)-2-benzylidene-6-((1-(2-(pyrrolidin-1-yl) ethyl)-1 H …
pyrrolidine-triazole-aurone hybrids ie (Z)-2-benzylidene-6-((1-(2-(pyrrolidin-1-yl) ethyl)-1 H …
New nitazoxanide derivatives: design, synthesis, biological evaluation, and molecular docking studies as antibacterial and antimycobacterial agents
M Saleh, YA Mostafa, J Kumari, MM Thabet… - RSC Medicinal …, 2023 - pubs.rsc.org
A new series inspired by combining fragments from nitazoxanide (NTZ) and 4-aminosalicylic
acid (4-ASA) was synthesized and screened for in vitro antibacterial and antimycobacterial …
acid (4-ASA) was synthesized and screened for in vitro antibacterial and antimycobacterial …