Alterations in the oral microbiome in HIV infection: causes, effects and potential interventions

S Li, B Su, QS He, H Wu, T Zhang - Chinese medical journal, 2021 - mednexus.org
A massive depletion of CD4+ T lymphocytes has been described in early and acute human
immunodeficiency virus (HIV) infection, leading to an imbalance between the human …

HIV-associated interactions between oral microbiota and mucosal immune cells: knowledge gaps and future directions

MO Coker, C Cairo, A Garzino-Demo - Frontiers in immunology, 2021 - frontiersin.org
Even with sustained use of antiretroviral therapy (ART), HIV-infected individuals have an
increased risk of systemic comorbid conditions and oral pathologies, including opportunistic …

Differential signature of the microbiome and neutrophils in the oral cavity of HIV-infected individuals

E Perez Rosero, S Heron, J Jovel, CR O'Neil… - Frontiers in …, 2021 - frontiersin.org
HIV infection is associated with a wide range of changes in microbial communities and
immune cell components of the oral cavity. The purpose of this study was to evaluate the …

Cannabinoid control of gingival immune activation in chronically SIV-infected rhesus macaques involves modulation of the indoleamine-2, 3-dioxygenase-1 pathway …

M McDew-White, E Lee, X Alvarez, K Sestak, BJ Ling… - …, 2022 - thelancet.com
Background HIV/SIV-associated periodontal disease (gingivitis/periodontitis)(PD) represents
a major comorbidity affecting people living with HIV (PLWH) on combination anti-retroviral …

Dental caries and its association with the oral microbiomes and HIV in young children—Nigeria (DOMHaIN): a cohort study

MO Coker, P Akhigbe, E Osagie, NL Idemudia… - BMC Oral Health, 2021 - Springer
Background This study seeks to understand better the mechanisms underlying the
increased risk of caries in HIV-infected school-aged Nigerian children by examining the …

Alteration in oral microbiome among men who have sex with men with acute and chronic HIV infection on antiretroviral therapy

S Li, J Zhu, B Su, H Wei, F Chen, H Liu… - Frontiers in Cellular …, 2021 - frontiersin.org
Despite the antiretroviral therapy (ART), human immunodeficiency virus (HIV)-related oral
disease remains a common problem for people living with HIV (PLWH). Evidence suggests …

Age-specific associations with dental caries in HIV-infected, exposed but uninfected and HIV-unexposed uninfected children in Nigeria

P Akhigbe, NM Chukwumah, MO Folayan, K Divaris… - BMC Oral Health, 2022 - Springer
Background HIV infection and its management confer a substantial health burden to affected
individuals and have been associated with increased risk of oral and dental diseases. In this …

Immune status, and not HIV infection or exposure, drives the development of the oral microbiota

MO Coker, EF Mongodin, SS El-Kamary, P Akhigbe… - Scientific reports, 2020 - nature.com
Even with antiretroviral therapy, children born to HIV-infected (HI) mothers are at a higher
risk of early-life infections and morbidities including dental disease. The increased risk of …

Effect of HIV/HAART and other clinical variables on the oral mycobiome using multivariate analyses

PL Fidel Jr, ZA Thompson, EA Lilly, C Granada… - MBio, 2021 - Am Soc Microbiol
The oral microbiome is considered an important factor in health and disease. We recently
reported significant effects of HIV and several other clinical variables on the oral bacterial …

Independent effects of HIV and antiretroviral therapy on the oral microbiome identified by multivariate analyses

CJ Beall, EA Lilly, C Granada, K Treas, KR Dubois III… - Mbio, 2023 - Am Soc Microbiol
The oral microbiome is an important predictor of health and disease. We recently reported
significant yet modest effects of HIV under highly active antiretroviral therapy (ART) on the …