Microglia Signaling in Health and Disease–Implications in Sex-Specific Brain Development and Plasticity
S Pramanik, MH Devi, S Chakrabarty, B Paylar… - Neuroscience & …, 2024 - Elsevier
Microglia, the intrinsic neuroimmune cells residing in the central nervous system (CNS),
exert a pivotal influence on brain development, homeostasis, and functionality …
exert a pivotal influence on brain development, homeostasis, and functionality …
Estradiol improves behavior in FAD transgenic mice that express APOE3 but not APOE4 after ovariectomy
D Balu, AC Valencia-Olvera, A Deshpande… - Frontiers in …, 2024 - frontiersin.org
Increasing evidence suggests that female individuals have a higher Alzheimer's disease
(AD) risk associated with post-menopausal loss of circulating estradiol (E2). However …
(AD) risk associated with post-menopausal loss of circulating estradiol (E2). However …
APOE2 Heterozygosity Reduces Hippocampal Soluble Amyloid-β42 Levels in Non-Hyperlipidemic Mice
AC Valencia-Olvera, D Balu, A Moore… - Journal of …, 2024 - content.iospress.com
APOE2lowers Alzheimer's disease (AD) risk; unfortunately, the mechanism remains poorly
understood and the use of mice models is problematic as APOE2 homozygosity is …
understood and the use of mice models is problematic as APOE2 homozygosity is …
Inflammaging in the Alzheimer's Brain and Beyond: Insights from a Transgenic Mouse Model on the Sex-specific Pathophysiology of Alzheimer's Disease
AJ Barber - 2024 - digitalcommons.dartmouth.edu
Aging and sex are major risk factors for developing late-onset Alzheimer's disease.
Compared to men, women experience worse neuropathological burden and cognitive …
Compared to men, women experience worse neuropathological burden and cognitive …
The effects of APOE4 and familial Alzheimer's disease mutations on free fatty acid profiles in mouse brain are age‐ and sex‐dependent
S den Hoedt, SM Crivelli… - Journal of …, 2015 - Wiley Online Library
APOE4 encoding apolipoprotein (Apo) E4 is the strongest genetic risk factor for Alzheimer's
disease (AD). ApoE is key in intercellular lipid trafficking. Fatty acids are essential for brain …
disease (AD). ApoE is key in intercellular lipid trafficking. Fatty acids are essential for brain …