Detection of toxic small molecule contaminants with sensitivity, accuracy, and specificity is a
challenging task. Traditionally used HPLC and mass spectrometry-based assays suffer from …

The field of aptamer-based sensing has evolved considerably over the past three decades.
The aptamer sensor-based detection of small-molecule targets in body fluids is designed for …

Little is known about the biological roles of glycosylated RNAs (glycoRNAs), a recently
discovered class of glycosylated molecules, because of a lack of visualization methods. We …

Nowadays, there is a high demand for sensitive and selective real-time analytical methods
suitable for a wide range of applications, from personalized telemedicine, drug discovery …

Aptamers are oligonucleotide receptors with great potential for sensing and therapeutic
applications. They are isolated from random libraries through an in vitro method termed …

Fipronil is a broad-spectrum insecticide widely used in agriculture and residential areas; its
indiscriminate use leads to environmental pollution and poses health hazards. Early …

Malathion is an organophosphate chemical (OPC) and a toxic contaminant that adversely
impacts food quality, human health, biodiversity, and the environment. Due to its small size …

Highlights•An aptamer with high affinity, high specificity, and high stability for binding to both
human-derived and rat-derived GDF15 was obtained.• The molecular mechanism and key …

Conventional directed evolution methods offer the ability to select bioreceptors with high
binding affinity for a specific target in terms of thermodynamic properties. However, there is a …

The percentage of low response and adaptive resistance to current antibody‐based immune
checkpoint blockade (ICB) therapy requires the development of novel immunotherapy …